Harmine  (Synonyms: Telepathine)

Harmine (GMP) (Telepathine (GMP)) is Harmine (HY-N0737A) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM^[1].

Harmine (GMP) inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC₅₀ of 190 nM^[2]. Harmine (GMP) negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine (GMP) significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine (GMP) treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine (GMP) significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine (GMP) treatment. The neuronal survival rate in the Harmine (GMP)-treated group is significantly increased, compared with the TBI group. Administration of Harmine (GMP) results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine (GMP) significantly reduces the expression of caspase 3, compared with the TBI group^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

212.25

C₁₃H₁₂N₂O

442-51-3

Solid

White to off-white

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32.  [Content Brief]

  [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859.  [Content Brief]

  [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92.  [Content Brief]

  [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91.  [Content Brief]