Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): synthesis of novel triazolyl substituted quinolines as potential anticancer agents

  • Bioorg Med Chem Lett. 2012 May 15;22(10):3455-9. doi: 10.1016/j.bmcl.2012.03.091.
Amarender Reddy Ellanki  1 ,  Aminul Islam ,  Veera Swamy Rama ,  Ranga Prasad Pulipati ,  D Rambabu ,  G Rama Krishna ,  C Malla Reddy ,  K Mukkanti ,  G R Vanaja ,  Arunasree M Kalle ,  K Shiva Kumar ,  Manojit Pal
Affiliations
  • 1. Chemistry-Technology Development Center, Dr. Reddy's Laboratories Limited, Miyapur, Hyderabad, Andhra Pradesh, India.
PMID: 22516283 DOI: 10.1016/j.bmcl.2012.03.091
Abstract

A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et(3)N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast Cancer cells.