Pi-delocalized beta-carbolinium cations as potential antimalarials

  • Bioorg Med Chem Lett. 2004 Apr 5;14(7):1689-92. doi: 10.1016/j.bmcl.2004.01.055.
Kiyosei Takasu  1 ,  Tsubasa Shimogama ,  Chalerm Saiin ,  Hye-Sook Kim ,  Yusuke Wataya ,  Masataka Ihara
Affiliations
  • 1. Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan. [email protected]
PMID: 15026051 DOI: 10.1016/j.bmcl.2004.01.055
Abstract

Several beta-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral beta-carbolines and a good correlation was observed between pi-delocalized lipophilic cationic structure and antimalarial efficacy.