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Cat. No.: HY-158212

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Dyrk1A-IN-8

Dyrk1A-IN-8 (compound 4C) is a potent inhibitor of Dyrk1A , with the IC₅₀ of 209 nM. Dyrk1A-IN-8 plays an important role in neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 101578-13-6
Formula: C₁₇H₂₁N₃O
Molecular Weight:283.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Dyrk1A-IN-8 Chemical Structure

CAS No.: 101578-13-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Dyrk1A-IN-8 (compound 4C) is a potent inhibitor of Dyrk1A , with the IC₅₀ of 209 nM. Dyrk1A-IN-8 plays an important role in neurodegenerative diseases^[1].

IC₅₀ & Target

DYRK1A

209 nM (IC₅₀)

All DYRK Isoforms :

Chemical Information

CAS No. 101578-13-6
Molecular Weight 283.37
Formula C₁₇H₂₁N₃O
SMILES

CC1=NC=CC2=C1N(C3=CC(OC)=CC=C32)CCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hunter T Warren, et al. Psychoplastogenic DYRK1A Inhibitors with Therapeutic Effects Relevant to Alzheimer’s Disease. J Med Chem. 2024 May 9;67(9):6922-6937. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Dyrk1A-IN-8

All DYRK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Dyrk1A-IN-8 Related Classifications

HY-158212 Related Classifications