2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. BW 245C

BW 245C 

Cat. No.: HY-101987 Purity: 99.14%
COA Handling Instructions

BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.

For research use only. We do not sell to patients.

BW 245C Chemical Structure

BW 245C Chemical Structure

CAS No. : 72814-32-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 608 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 608 In-stock
Solid
1 mg USD 250 In-stock
5 mg USD 750 In-stock
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50 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

BW 245C Related Antibodies

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Description

BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.

IC50 & Target[1]

DP

 

In Vitro

BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts[3]. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BW 245C Related Antibodies
In Vivo

BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1−/− mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1−/− mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group[1]. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

368.47

Appearance

Solid

Formula

C19H32N2O5
CAS No.
SMILES

O=C(O)CCCCCC[C@@H](C(N1)=O)N(CC[C@H](C2CCCCC2)O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (135.70 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7139 mL 13.5696 mL 27.1392 mL
5 mM 0.5428 mL 2.7139 mL 5.4279 mL
10 mM 0.2714 mL 1.3570 mL 2.7139 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.14%

COA (250 KB) LCMS (325 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

The mice are untreated or given an i.p. injection of the vehicle (1% DMSO) or 0.2-mg/kg BW245C. Thirty minutes after the injection, the mice are anesthetized and placed on a thermoregulated pad to maintain body temperature, and 3 mm of the tail tip is excised. The tail is immediately dipped in warm PBS (37.0±0.5°C) and time to visible cessation of bleeding is recorded.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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BW 245C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BW 245C72814-32-5Prostaglandin ReceptorInhibitorinhibitorinhibit

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