2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Prostaglandin Receptor Serotonin Transporter Aldose Reductase Cytochrome P450
  4. AZ-11665362

AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC50 of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases.

For research use only. We do not sell to patients.

AZ-11665362

AZ-11665362 Chemical Structure

CAS No. : 629645-40-5

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AZ-11665362 Related Antibodies

Top Publications Citing Use of Products

View All Prostaglandin Receptor Isoform Specific Products:

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DP EP FP IP TXA2/TP TXB2

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC50 of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases[1].

IC50 & Target[1]

DP2

2.6 nM (IC50)

CYP2C19

2.5 μM (IC50)

CYP2C9

5 μM (IC50)

In Vitro

AZ-11665362 (Compound 12) potently binds to human CRTh2 expressed in HEK 293 cells, with an IC50 of 2.6 nM[1].
AZ-11665362 shows selective activity against rat aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9 (IC50 values of 150, 2000, 2500 and 5000 μM), with no measurable activity against COX-1 or COX-2 at 3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZ-11665362 Related Antibodies
Molecular Weight

344.41

Formula

C22H20N2O2
CAS No.
SMILES

O=C(O)CN1C=2C=CC(=CC2C(C=3C=CN=C4C3C=CC=C4C)=C1C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZ-11665362 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ-11665362629645-40-5AZ11665362AZ 11665362Prostaglandin ReceptorSerotonin TransporterAldose ReductaseCytochrome P4505-HTTSERTSLC6A4CYPsHEK 293 cellsCOX-2serotonin transporterhERG channelrat aldose reductaseCYP 2C9CRTh2 (DP2) receptorCOX-1DP1 receptorCYP 2C19Inhibitorinhibitorinhibit

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