AZ-11665362
AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC50 of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 629645-40-5
- Fòrmula: C22H20N2O2
- Peso molecular:344.41
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
DP2 2.6 nM (IC50) |
CYP2C19 2.5 μM (IC50) |
CYP2C9 5 μM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
2.6 nM
Compound: 12
|
Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells
Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells
|
[PMID: 16753296] |
In Vitro
AZ-11665362 (Compound 12) potently binds to human CRTh2 expressed in HEK 293 cells, with an IC50 of 2.6 nM[1].
AZ-11665362 shows selective activity against rat aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9 (IC50 values of 150, 2000, 2500 and 5000 μM), with no measurable activity against COX-1 or COX-2 at 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 629645-40-5
-
Peso molecular 344.41
-
Fòrmula C22H20N2O2
-
SMILES
O=C(O)CN1C=2C=CC(=CC2C(C=3C=CN=C4C3C=CC=C4C)=C1C)C
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ-11665362 Related Classifications
HY-116811 Related Classifications
Powered by Bioz