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Cat. No.: HY-116811

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AZ-11665362

AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC₅₀ of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases.

For research use only. We do not sell to patients.

CAS No.: 629645-40-5
Formula: C₂₂H₂₀N₂O₂
Molecular Weight:344.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZ-11665362 Chemical Structure

CAS No.: 629645-40-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

DP2

2.6 nM (IC₅₀)

CYP2C19

2.5 μM (IC₅₀)

CYP2C9

5 μM (IC₅₀)

All Prostaglandin Receptor Isoforms :

All Cytochrome P450 Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	2.6 nM Compound: 12	Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells Displacement of [3H]PGD2 from human CRTh2 expressed in HEK293 cells	[PMID: 16753296]

In Vitro

AZ-11665362 (Compound 12) potently binds to human CRTh2 expressed in HEK 293 cells, with an IC₅₀ of 2.6 nM^[1].
AZ-11665362 shows selective activity against rat aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9 (IC₅₀ values of 150, 2000, 2500 and 5000 μM), with no measurable activity against COX-1 or COX-2 at 3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 629645-40-5
Molecular Weight 344.41
Formula C₂₂H₂₀N₂O₂
SMILES

O=C(O)CN1C=2C=CC(=CC2C(C=3C=CN=C4C3C=CC=C4C)=C1C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Birkinshaw TN, et al. Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4287-90. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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AZ-11665362

All Prostaglandin Receptor Isoforms

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AZ-11665362 Related Classifications

HY-116811 Related Classifications