AL-6556 

AL-6556 is a full agonist of the DP receptor and a partial agonist of the EP2 receptor. AL-6556 has an EC₅₀ of 799 nM for bovine DP, a K_i of 3200 nM for human DP, and an EC₅₀ of 1180 nM for human EP2, with selectivity over EP3, FP, IP, TP and 19 non-prostaglandin receptors. AL-6556 stimulates cAMP production via receptor activation and reduces intraocular pressure through aqueous humor inflow and outflow mechanisms. AL-6556 can be used in research related to ocular hypertension and glaucoma^[1].

AL-6556 (0.1 nM-100 μM) shows highest affinity for human platelet DP receptors with a K_i of 3200 nM, 21-37-fold selectivity over EP3, FP, IP, and TP prostanoid receptors, and moderate affinity for EP1 and EP4 receptors^[1].
AL-6556 (10 μM) weakly interacts with most nonprostanoid receptors, with the strongest inhibition (47.5%) observed at the platelet activating factor receptor^[1].
AL-6556 (0.1 nM-100 μM; 15 min) acts as a full agonist at embryonic bovine tracheal fibroblast DP receptors, stimulating cAMP production with an EC₅₀ of 799 nM and 93% maximum efficacy relative to PGD₂^[1].
AL-6556 (0.1 nM-100 μM; 15 min) acts as a partial agonist at human nonpigmented epithelial cell EP2 receptors, stimulating cAMP production with an EC₅₀ of 1180 nM and 35% maximum efficacy relative to PGE₂, with no agonist activity at EP4, IP, or FP receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

388.93

C₂₀H₃₃ClO₅

170552-18-8

O[C@@H](C1CCCCC1)CC[C@@H]2[C@H]([C@@H](C[C@H]2O)Cl)C/C=C\COCC(O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sharif NA, et al. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes. J Ocul Pharmacol Ther. 2004;20(6):489-508.