170552-18-8
Chemical Structure
AL-6556
- CAS No.: 170552-18-8
- Formula:C20H33ClO5
- Molecular Weight:388.93
InChIKey: WSKYUCGYZSXRPF-HOEVUQABSA-N
SMILES: O[C@@H](C1CCCCC1)CC[C@@H]2[C@H]([C@@H](C[C@H]2O)Cl)C/C=C\COCC(O)=O
Biological Activity: AL-6556 is a full agonist of the DP receptor and a partial agonist of the EP2 receptor. AL-6556 has an EC50 of 799 nM for bovine DP, a Ki of 3200 nM for human DP, and an EC50 of 1180 nM for human EP2, with selectivity over EP3, FP, IP, TP and 19 non-prostaglandin receptors. AL-6556 stimulates cAMP production via receptor activation and reduces intraocular pressure through aqueous humor inflow and outflow mechanisms. AL-6556 can be used in research related to ocular hypertension and glaucoma[1].
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AL-6556 | AL-6556 is a full agonist of the DP receptor and a partial agonist of the EP2 receptor. AL-6556 has an EC50 of 799 nM for bovine DP, a Ki of 3200 nM for human DP, and an EC50 of 1180 nM for human EP2, with selectivity over EP3, FP, IP, TP and 19 non-prostaglandin receptors. AL-6556 stimulates cAMP production via receptor activation and reduces intraocular pressure through aqueous humor inflow and outflow mechanisms. AL-6556 can be used in research related to ocular hypertension and glaucoma. | |||||||||||||||||||||
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Keywords
