2. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  3. Histamine Receptor
    Leukotriene Receptor
    Prostaglandin Receptor
  4. Nedocromil

Nedocromil  (Synonyms: FPL 59002)

Cat. No.: HY-13448 Purity: 98.02%
COA Handling Instructions

Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

For research use only. We do not sell to patients.

Nedocromil Chemical Structure

Nedocromil Chemical Structure

CAS No. : 69049-73-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 106 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 130 In-stock
25 mg USD 260 In-stock
50 mg USD 420 In-stock
100 mg USD 660 In-stock
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This product is a controlled substance and not for sale in your territory.

Other Forms of Nedocromil:

Top Publications Citing Use of Products

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LTB4 LTC4 LTD4/CysLT1 LTE4 CysLT2 CysLT1

  • Biological Activity

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  • References

  • Customer Review

Description

Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

IC50 & Target[1]

Histamine

 

LTC4

 

PGD2

 

In Vitro

Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

371.34

Appearance

Solid

Formula

C19H17NO7
CAS No.
SMILES

O=C(C1=CC(C2=CC3=C(N(CC)C(C(O)=O)=CC3=O)C(CCC)=C2O1)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (44.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6929 mL 13.4647 mL 26.9295 mL
5 mM 0.5386 mL 2.6930 mL 5.3859 mL
10 mM 0.2693 mL 1.3465 mL 2.6930 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.02%

COA (248 KB) HNMR (254 KB) RP-HPLC (250 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[2]

Mice[2]
8-12 weeks old C57/BL6 male mice between 23-25 g receive intraperitoneal (i.p.) injections of 50 mg/kg Streptozotocin (STZ), dissolved in 100 mM citrate buffer pH 4.5, for five consecutive days. Diabetic mice (13-week-old) are randomly divided into three groups: 1) untreated group; 2) Nedocromil group, with Nedocromil released at the rate of 30 mg/kg per day from a subcutaneous (s.c.) pellet implantation; and vehicle group, with an inactive pellet implanted. Normal mice (non-diabetic) and normal mice that receive Nedocromil (30 mg/kg per day) are also included in this study for comparison. All sample groups included 15 mice (n=15)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Nedocromil69049-73-6FPL 59002FPL59002FPL-59002Histamine ReceptorLeukotriene ReceptorProstaglandin ReceptorInhibitorinhibitorinhibit

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