1. GPCR/G Protein
    Neuronal Signaling
  2. Histamine Receptor
    Leukotriene Receptor
    Prostaglandin Receptor
  3. Nedocromil sodium

Nedocromil sodium (Synonyms: FPL 59002KP; Nedocromil disodium salt)

Cat. No.: HY-16344
Handling Instructions

Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

For research use only. We do not sell to patients.

Nedocromil sodium Chemical Structure

Nedocromil sodium Chemical Structure

CAS No. : 69049-74-7

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Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

IC50 & Target[1]







In Vitro

Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively)[1].

In Vivo

Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function[2].

Clinical Trial
Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 5.2 mg/mL (12.52 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4079 mL 12.0395 mL 24.0790 mL
5 mM 0.4816 mL 2.4079 mL 4.8158 mL
10 mM 0.2408 mL 1.2039 mL 2.4079 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.52 mg/mL (1.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.52 mg/mL (1.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.52 mg/mL (1.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
Animal Administration

8-12 weeks old C57/BL6 male mice between 23-25 g receive intraperitoneal (i.p.) injections of 50 mg/kg Streptozotocin (STZ), dissolved in 100 mM citrate buffer pH 4.5, for five consecutive days. Diabetic mice (13-week-old) are randomly divided into three groups: 1) untreated group; 2) Nedocromil group, with Nedocromil released at the rate of 30 mg/kg per day from a subcutaneous (s.c.) pellet implantation; and vehicle group, with an inactive pellet implanted. Normal mice (non-diabetic) and normal mice that receive Nedocromil (30 mg/kg per day) are also included in this study for comparison. All sample groups included 15 mice (n=15)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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NedocromilFPL 59002KP Nedocromil disodiumHistamine ReceptorLeukotriene ReceptorProstaglandin ReceptorInhibitorinhibitorinhibit

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