69049-73-6
Chemical Structure
Nedocromil
Synonym(s): FPL 59002
- CAS No.: 69049-73-6
- Formula:C19H17NO7
- Molecular Weight:371.34
IUPAC Name: 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
InChIKey: RQTOOFIXOKYGAN-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=CC3=C(N(CC)C(C(O)=O)=CC3=O)C(CCC)=C2O1)=O)O
Biological Activity: Nedocromil (FPL 59002) is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nedocromil | 98.19% | Nedocromil (FPL 59002) is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis. | ||||||||||||||||||||
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Nedocromil (Standard) | ≥98% | Nedocromil (FPL 59002) (Standard) is the analytical standard of Nedocromil (HY-13448). This product is intended for research and analytical applications. Nedocromil (FPL 59002) calcium is a mast cell stabilizer and an inhibitor of IL-8 production. Nedocromil calcium inhibits mast cell degranulation and collagen synthesis induced by activated mast cells, indirectly interfering with IL-1β signaling. Nedocromil calcium reduces conjunctival eosinophil infiltration and improves the cutaneous manifestations of chronic graft-versus-host disease (including reducing fibrosis, loss of fat and hair follicles, and inflammatory infiltration). Nedocromil calcium can be used in research on chronic graft-versus-host disease, asthma, and allergic conjunctivitis. | ||||||||||||||||||||
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References
- [1]. Levi-Schaffer F, et al. Nedocromil sodium ameliorates skin manifestations in a murine model of chronic graft-versus-host disease. Bone marrow transplantation. 1997 Apr;19(8):823-8.
- [2]. Vittori E, et al. Protective effect of nedocromil sodium on the interleukin-1-induced production of interleukin-8 in human bronchial epithelial cells. The Journal of allergy and clinical immunology. 1992 Jul;90(1):76-84.
- [3]. Merayo-Lloves J, et al. A new murine model of allergic conjunctivitis and effectiveness of nedocromil sodium. The Journal of allergy and clinical immunology. 1996 May;97(5):1129-40.
