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Isoforms Recommended:	LTA4H

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leukotriene-a4-hydrolase

" in MedChemExpress (MCE) Product Catalog:

標的別:	Aminopeptidase (20) Antibiotic (7) Bacterial (7) Biochemical Assay Reagents (1) Endogenous Metabolite (1) Fluorescent Dye (1) Isotope-Labeled Compounds (2) Leukotriene Receptor (4) Opioid Receptor (1) Reference Standards (4)
研究分野別:	Cancer (7) Cardiovascular Disease (1) Infection (7) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (2)

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製品番号	製品名	Target	研究分野	構造式

HY-B0134

Bestatin 10+ Cited Publications Ubenimex	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase* inhibitor. Bestatin has anticancer effects .

HY-B0134A

Bestatin hydrochloride 10+ Cited Publications Ubenimex hydrochloride	Antibiotic Bacterial Aminopeptidase	Infection Cancer
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase*, used for cancer research.

HY-17625

Acebilustat 1 Publications Verification CTX-4430	Aminopeptidase	Inflammation/Immunology
Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory agent.

HY-137298

LYS006 LTa4H-IN-1	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-1 is a potent inhibitor of **leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC₅₀** of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders .

HY-U00452

PL553	Fluorescent Dye	Inflammation/Immunology
PL553 is a specific and high-affinity fluorigenic substrate of Leukotriene A4 hydrolase, with a λ_max of 210 nm and λ_em of 410 nm.

HY-10825

DG051 1 Publications Verification	Aminopeptidase	Metabolic Disease
DG051 is a potent *leukotriene A4 hydrolase* inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC₅₀=47 nM.

HY-B0134AS

Bestatin-d7 hydrochloride Ubenimex-d7 hydrochloride	Isotope-Labeled Compounds Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-W097753

4-MDM 4-Methoxydiphenylmethane	Aminopeptidase	Others
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A₄ Hydrolase (LTA₄H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by *LTA₄H, thereby reducing inflammation, and does not affect the epoxy-hydrolase* activity of *LTA₄H*. 4-MDM can be used for research on lung diseases .

HY-B0134R

Bestatin (Standard) Ubenimex (Standard)	Reference Standards Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase* inhibitor. Bestatin has anticancer effects .

HY-115500

PL265	Endogenous Metabolite Opioid Receptor Leukotriene Receptor	Neurological Disease Inflammation/Immunology
PL265 is an orally active dual enkephalinase inhibitor. PL265 is a prodrug of PL254, which can simultaneously and efficiently inhibit neutral endopeptidase (Neprilysin) and Aminopeptidase N. PL265 can effectively protect and significantly increase the local concentration of enkephalins (such as Met-Enkephalin and Leu-Enkephalin) released by cells at the pain or inflammation sites, thereby activating μ and δ opioid receptors to produce a potent analgesic effect. PL254 can also inhibit leukotriene A4 hydrolase (LTA4H), which may contribute to its additional anti-inflammatory effect by reducing the production of pro-inflammatory mediator leukotriene B4 (LTB4). PL265 can be used in non-addictive chronic pain research .

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin trifluoroacetate is an inhibitor of CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase*, used for cancer research.

HY-119023

JNJ-26993135	Aminopeptidase	Inflammation/Immunology
JNJ-26993135 is a selective leukotriene A4 hydrolase (LTA4H) inhibitor with the IC₅₀ value of 11 nM .

HY-162015

LTA4H-IN-2	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-2 (compound (S)-2 ) is an orally active inhibitor of *Leukotriene A4 Hydrolase*, with an IC₅₀ of <3 nM .

HY-17625R

Acebilustat (Standard) CTX-4430 (Standard)	Aminopeptidase Reference Standards	Inflammation/Immunology
Acebilustat (Standard) is the analytical standard of Acebilustat. This product is intended for research and analytical applications. Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory agent.

HY-B0134AR

Bestatin hydrochloride (Standard) Ubenimex hydrochloride (Standard)	Reference Standards Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin (hydrochloride) (Standard) is the analytical standard of Bestatin (hydrochloride). This product is intended for research and analytical applications. Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-137298A

LYS006 hydrochloride	Aminopeptidase	Metabolic Disease Inflammation/Immunology
LYS006 hydrochloride is a potent inhibitor of **leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC₅₀** of 2 nM. LYS006 hydrochloride can be used for the research of inflammatory and autoimmune disorders .

HY-B0134S1

Bestatin-d10 Ubenimex-d₁₀	Isotope-Labeled Compounds Bacterial Antibiotic Aminopeptidase	Infection Cancer
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase* inhibitor. Bestatin has anticancer effects .

HY-156960

JNJ-40929837	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 is a selective and orally active *LTA₄H* (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .

HY-156960A

JNJ-40929837 succinate	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 succinate is a selective and orally active *LTA₄H* (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .

HY-10826

DG051 free acid	Aminopeptidase	Cardiovascular Disease Neurological Disease
DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a K_d of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke .

HY-162710

LTA4H-IN-5	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-5 (Compound H122) is an orally active inhibitor for *leukotriene A4 hydrolase* (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC₅₀ of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models .

HY-W612175

H-Ala-pNA	Leukotriene Receptor	Others
H-Ala-pNA is an L-amino acid p-nitroaniline (pNA) derivative and a specific substrate for *leukotriene A4 hydrolase. The D-enantiomer of H-Ala-pNA shows no activity toward leukotriene A4 hydrolase. H-Ala-pNA can be catalytically hydrolyzed by leukotriene A4 hydrolase, and the p-nitroaniline produced during the reaction is monitored spectrophotometrically at 405 nm* to enable quantitative detection of enzyme activity. H-Ala-pNA is used to evaluate the potency of inhibitors targeting the amidase activity of leukotriene A4 hydrolase .

HY-W274294

H-Pro-Pna	Biochemical Assay Reagents	Others
H-Pro-Pna is a chromogenic substrate of peptidase and can be used to determine enzyme activity, such as leukotriene A4 hydrolase .

HY-10825R

DG051 (Standard)	Reference Standards Aminopeptidase	Metabolic Disease
DG051 (Standard) is the analytical standard of DG051 (HY-10825). This product is intended for research and analytical applications. DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC₅₀=47 nM.

製品番号	製品名	Type

HY-U00452

PL553	蛍光色素
PL553 is a specific and high-affinity fluorigenic substrate of Leukotriene A4 hydrolase, with a λ_max of 210 nm and λ_em of 410 nm.

Bestatin 10+ Cited Publications Ubenimex	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase* inhibitor. Bestatin has anticancer effects .

Bestatin hydrochloride 10+ Cited Publications Ubenimex hydrochloride	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Antibiotic Bacterial Aminopeptidase
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase*, used for cancer research.

Bestatin (Standard) Ubenimex (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aminopeptidase Bacterial Antibiotic
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase* inhibitor. Bestatin has anticancer effects .

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Aminopeptidase Bacterial Antibiotic
Bestatin trifluoroacetate is an inhibitor of CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase*, used for cancer research.

Bestatin hydrochloride (Standard) Ubenimex hydrochloride (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aminopeptidase Bacterial Antibiotic
Bestatin (hydrochloride) (Standard) is the analytical standard of Bestatin (hydrochloride). This product is intended for research and analytical applications. Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (1) Sf9 insect cells (2)

製品番号	Compare	製品名	Species	Source	Image

HY-P70277

	Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His) rHuleukotriene A-4 hydrolase/LTa4H, His; leukotriene A-4 hydrolase; LTA-4 hydrolase; leukotriene A(4) hydrolase; LTa4; LTa4H	Human	HEK293
	The leukotriene A4 hydrolase/LTA4H protein is a bifunctional zinc metalloenzyme that functions as an epoxide hydrolase to convert LTA4 to the proinflammatory mediator LTB4 and exhibits aminopeptidase activity targeting the N-terminal arginine. In addition to its pro-inflammatory effects, LTA4H also combats inflammation by inactivating the neutrophil attractant Pro-Gly-Pro. Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His) is the recombinant human-derived Leukotriene A4 Hydrolase/LTA4H protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74776

	Leukotriene A4 Hydrolase/LTA4H Protein, Mouse (sf9, His) Leukemia inhibitory factor; leukotriene A-4 hydrolase; LTA-4 hydrolase; LTa4H	Mouse	Sf9 insect cells
	The LTA4H protein is a bifunctional zinc metalloenzyme that acts as an epoxide hydrolase to convert leukotriene A4 (LTA4) into proinflammatory leukotriene B4 (LTB4).It also acts as an aminopeptidase, cleaving N-terminal arginine and fighting inflammation, particularly through Pro-Gly-Pro (PGP) cleavage.Leukotriene A4 Hydrolase/LTA4H Protein, Mouse (sf9, His) is the recombinant mouse-derived Leukotriene A4 Hydrolase/LTA4H protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P73275

	Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His) Leukemia inhibitory factor; leukotriene A-4 hydrolase; LTA-4 hydrolase; LTa4H	Human	Sf9 insect cells
	The leukotriene A4 hydrolase/LTA4H protein is a bifunctional zinc metalloenzyme that functions as an epoxide hydrolase to convert LTA4 to the proinflammatory mediator LTB4 and exhibits aminopeptidase activity targeting the N-terminal arginine. In addition to its pro-inflammatory effects, LTA4H also combats inflammation by inactivating the neutrophil attractant Pro-Gly-Pro. Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His) is the recombinant human-derived Leukotriene A4 Hydrolase/LTA4H protein, expressed by Sf9 insect cells , with C-His labeled tag.

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HY-B0134AS

Bestatin-d7 hydrochloride
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-B0134S1

Bestatin-d10
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and *leukotriene A4 hydrolase* inhibitor. Bestatin has anticancer effects .

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P82655

	Leukotriene A4 Hydrolase Antibody (YA2400) LTa4; LTa4 hydrolase; LTa4H	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Leukotriene A4 Hydrolase Antibody (YA2400) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Leukotriene A4 Hydrolase.

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