LTA4H-IN-5
LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models.
For research use only. We do not sell to patients.
- Formula: C18H17Cl2FN4O4
- Molecular Weight:443.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
LTA4H aminopeptidase 0.38 nM (IC50) |
LTA4H aminopeptidase 16.93 nM (IC50) |
Chemical Information
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Molecular Weight 443.26
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Formula C18H17Cl2FN4O4
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SMILES
ClC1=CN=C(OC2=CC(C)=C(C3=NOC(C[C@H](CC(O)=O)N)=N3)C=C2)C(F)=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LTA4H-IN-5 Related Classifications
HY-162710 Related Classifications
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