LTA4H-IN-5
LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models.
For research use only. We do not sell to patients.
- Formula: C18H17Cl2FN4O4
- Molecular Weight:443.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LTA4H aminopeptidase 0.38 nM (IC50) |
LTA4H aminopeptidase 16.93 nM (IC50) |
Chemical Information
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Molecular Weight 443.26
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Formula C18H17Cl2FN4O4
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SMILES
ClC1=CN=C(OC2=CC(C)=C(C3=NOC(C[C@H](CC(O)=O)N)=N3)C=C2)C(F)=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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