PL265
PL265 is an orally active dual enkephalinase inhibitor. PL265 is a prodrug of PL254, which can simultaneously and efficiently inhibit neutral endopeptidase (Neprilysin) and Aminopeptidase N. PL265 can effectively protect and significantly increase the local concentration of enkephalins (such as Met-Enkephalin and Leu-Enkephalin) released by cells at the pain or inflammation sites, thereby activating μ and δ opioid receptors to produce a potent analgesic effect. PL254 can also inhibit leukotriene A4 hydrolase (LTA4H), which may contribute to its additional anti-inflammatory effect by reducing the production of pro-inflammatory mediator leukotriene B4 (LTB4). PL265 can be used in non-addictive chronic pain research.
For research use only. We do not sell to patients.
- CAS No.: 1206514-50-2
- Formula: C28H37N2O9P
- Molecular Weight:576.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
MoreAll Opioid Receptor Isoforms
MoreAll Leukotriene Receptor Isoforms
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Biological Activity
Description
Chemical Information
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CAS No. 1206514-50-2
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Molecular Weight 576.58
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Formula C28H37N2O9P
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SMILES
CC(C)C(OC(C)OC(N[C@@H](C)P(C[C@@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C(N[C@@H](C)C(O)=O)=O)(O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PL265 Related Classifications
HY-115500 Related Classifications
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