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Cat. No.: HY-10826

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DG051 free acid

Name: DG051 free acid
Brand: MedChemExpress
SKU: HY-10826
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a K_d of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke.

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CAS No.: 929916-05-2
Formule: C₂₁H₂₄ClNO₄
Masse moléculaire:389.87

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Data Sheet (271 KB)

DG051 free acid Chemical Structure

CAS No.: 929916-05-2

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Description

Voir tous les produits spécifiques à Isoform Aminopeptidase :

CD13
LTA4H

Chemical Information

CAS No. 929916-05-2
Masse moléculaire 389.87
Formule C₂₁H₂₄ClNO₄
SMILES

ClC(C=C1)=CC=C1OC(C=C2)=CC=C2OC[C@H]3N(CCC3)CCCC(O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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bioRxiv

2023 Oct 23.

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Enache L A, et al. Development of a scalable synthetic process for DG-051B, a First-in-Class inhibitior of LTA4H[J]. Organic Process Research & Development, 2009, 13(6): 1177-1184.

[2]. Sandanayaka V, et al. Discovery of 4-[(2 S)-2-{[4-(4-chlorophenoxy) phenoxy] methyl}-1-pyrrolidinyl] butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis[J]. Journal of medicinal chemistry, 2010, 53(2): 573-585.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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1 Cited Publications

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DG051 free acid

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