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Cat. No.: HY-10826

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DG051 free acid

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a K_d of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke.

For research use only. We do not sell to patients.

CAS No.: 929916-05-2
Formula: C₂₁H₂₄ClNO₄
Molecular Weight:389.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DG051 free acid Chemical Structure

CAS No.: 929916-05-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Aminopeptidase Isoforms :

CD13
LTA4H

Chemical Information

CAS No. 929916-05-2
Molecular Weight 389.87
Formula C₂₁H₂₄ClNO₄
SMILES

ClC(C=C1)=CC=C1OC(C=C2)=CC=C2OC[C@H]3N(CCC3)CCCC(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2023 Oct 23.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Enache L A, et al. Development of a scalable synthetic process for DG-051B, a First-in-Class inhibitior of LTA4H[J]. Organic Process Research & Development, 2009, 13(6): 1177-1184.

[2]. Sandanayaka V, et al. Discovery of 4-[(2 S)-2-{[4-(4-chlorophenoxy) phenoxy] methyl}-1-pyrrolidinyl] butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis[J]. Journal of medicinal chemistry, 2010, 53(2): 573-585.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DG051 free acid

1 Cited Publications

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DG051 free acid

Publications Citing Use of MedChemExpress (MCE) DG051 free acid

All Aminopeptidase Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

DG051 free acid Related Classifications

Cat. No.: HY-10826