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Art. -Nr.: HY-10826

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DG051 free acid

Name: DG051 free acid
Brand: MedChemExpress
SKU: HY-10826
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a K_d of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke.

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CAS. Nr.: 929916-05-2
Formel: C₂₁H₂₄ClNO₄
Molecular Weight:389.87

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DG051 free acid Chemical Structure

CAS. Nr.: 929916-05-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Alle Aminopeptidase Isoform-spezifische Produkte anzeigen :

CD13
LTA4H

Chemical Information

CAS. Nr. 929916-05-2
Molecular Weight 389.87
Formel C₂₁H₂₄ClNO₄
SMILES

ClC(C=C1)=CC=C1OC(C=C2)=CC=C2OC[C@H]3N(CCC3)CCCC(O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2023 Oct 23.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Enache L A, et al. Development of a scalable synthetic process for DG-051B, a First-in-Class inhibitior of LTA4H[J]. Organic Process Research & Development, 2009, 13(6): 1177-1184.

[2]. Sandanayaka V, et al. Discovery of 4-[(2 S)-2-{[4-(4-chlorophenoxy) phenoxy] methyl}-1-pyrrolidinyl] butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis[J]. Journal of medicinal chemistry, 2010, 53(2): 573-585.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DG051 free acid

1 Cited Publications

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DG051 free acid

Publications Citing Use of MedChemExpress (MCE) DG051 free acid

Alle Aminopeptidase Isoform-spezifische Produkte anzeigen

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Publications (1)

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DG051 free acid

Publications Citing Use of MedChemExpress (MCE) DG051 free acid

Alle Aminopeptidase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Chemical Information

Publications (1)

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