New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis

  • J Nat Prod. 2003 Nov;66(11):1495-8. doi: 10.1021/np030162j.
Yujin Park  1 ,  Yonghong Liu ,  Jongki Hong ,  Chong-O Lee ,  Heeyeong Cho ,  Dong-Kyoo Kim ,  Kwang Sik Im ,  Jee H Jung
Affiliations
  • 1. College of Pharmacy, Pusan National University, Busan 609-735, Korea.
PMID: 14640526 DOI: 10.1021/np030162j
Abstract

Three new bromotyrosine derivatives (4-6) were isolated from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis, along with the previously described (E,E)-psammaplin A (1), (E,Z)-psammaplin A (2), psammaplin D (3), bisaprasin (7), and (3-bromo-4-hydroxyphenyl)acetonitrile (8). The structures of the new compounds were established on the basis of NMR and MS spectroscopic analysis. The compounds 1, 3, and 5-7 displayed significant cytotoxicity against human lung (A549), ovarian (SK-OV-3), skin (SK-MEL-2), CNS (XF498), and colon (HCT15) Cancer cell lines. Compounds 3-7 were further evaluated for Antibacterial activity against methicillin- or ofloxacin-resistant Staphylococcus strains. Compound 4 exhibited more potent Antibacterial activity than meropenem against several strains.