Cat. No.: HY-117738

Benarthin

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Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a K_d value of 5.13e-08 M) and competitive PGP-1 inhibitor (K_i = 1.2 µM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1-SFRP1 interaction, inhibits the activation of the GSK3α/β-β-catenin pathway, and reduces the upregulation of FASLG. Benarthin attenuates urothelial anoikis and reduces cell Apoptosis. Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones.

For research use only. We do not sell to patients.

Purity: 95.79%
CAS No.: 143651-45-0
Formula: C₁₇H₂₅N₅O₇
Molecular Weight:411.41

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Benarthin Chemical Structure

CAS No.: 143651-45-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]

Fungal Metabolite

GSK-3α

GSK-3β

All Aminopeptidase Isoforms :

CD13
LTA4H

All Endogenous Metabolite Isoforms :

All GSK-3 Isoforms :

In Vitro

Benarthin chelates iron^[1].
Benarthin (1-20 μM) inhibits FASLG in HAP-treated hRIF in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benarthin (p.o.) reduces Faslg expression in renal interstitial fibroblasts and enhances urothelial retention in mouse models of Randall's Plaque^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Umod^−/−and Npt2a^−/− mice^[2]
Dosage:

Not specified
Administration:

p.o. via drinking water
Result:

Reduced Faslg expression in Col1a2-labeled RIFs.
Increased Pxn expression and enhanced urothelial retention in mice.
Directly targeted THY1, disrupting its interaction with SFRP1, thereby inhibiting the GSK3α/β-β-catenin-FASLG axis and alleviating anodic apoptosis in RPSEC cells.

Chemical Information

CAS No. 143651-45-0
Appearance Solid
Molecular Weight 411.41
Formula C₁₇H₂₅N₅O₇
Color Off-white to gray
SMILES

C[C@H]([C@H](NC([C@@H](NC(C1=CC=CC(O)=C1O)=O)CCCNC(N)=N)=O)C(O)=O)O
Initial Source

Streptomyces sp. YM5-799
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (243.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4307 mL

12.1533 mL

24.3067 mL

5 mM

0.4861 mL

2.4307 mL

4.8613 mL

10 mM

0.2431 mL

1.2153 mL

2.4307 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matsuo Y, et al. Streptobactin, a tricatechol-type siderophore from marine-derived Streptomyces sp. YM5-799. J Nat Prod. 2011;74(11):2371-2376. [Content Brief]

[2]. Liu M, et al. FASLG Derived from Fibroblasts in Hydroxyapatite-Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure. Adv Sci (Weinh). Published online April 2, 2026. [Content Brief]

[3]. Zhang R, et al. Carnosic acid-loaded stimuli-responsive hydrogel promotes wound healing through PGP-1 mediated immune remodeling. J Nanobiotechnology. 2026;24(1):296. Published 2026 Feb 23. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4307 mL	12.1533 mL	24.3067 mL	60.7666 mL
	5 mM	0.4861 mL	2.4307 mL	4.8613 mL	12.1533 mL
	10 mM	0.2431 mL	1.2153 mL	2.4307 mL	6.0767 mL
	15 mM	0.1620 mL	0.8102 mL	1.6204 mL	4.0511 mL
	20 mM	0.1215 mL	0.6077 mL	1.2153 mL	3.0383 mL
	25 mM	0.0972 mL	0.4861 mL	0.9723 mL	2.4307 mL
	30 mM	0.0810 mL	0.4051 mL	0.8102 mL	2.0256 mL
	40 mM	0.0608 mL	0.3038 mL	0.6077 mL	1.5192 mL
	50 mM	0.0486 mL	0.2431 mL	0.4861 mL	1.2153 mL
	60 mM	0.0405 mL	0.2026 mL	0.4051 mL	1.0128 mL
	80 mM	0.0304 mL	0.1519 mL	0.3038 mL	0.7596 mL
	100 mM	0.0243 mL	0.1215 mL	0.2431 mL	0.6077 mL

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Benarthin

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All Aminopeptidase Isoforms

All Endogenous Metabolite Isoforms

All GSK-3 Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Benarthin Related Classifications

Cat. No.: HY-117738