143651-45-0
Chemical Structure
Benarthin
- CAS No.: 143651-45-0
- Formula:C17H25N5O7
- Molecular Weight:411.41
IUPAC Name: (2,3-dihydroxybenzoyl)-L-arginyl-L-threonine
InChIKey: RYFDAFYFFUVLNW-QRTLGDNMSA-N
SMILES: C[C@H]([C@H](NC([C@@H](NC(C1=CC=CC(O)=C1O)=O)CCCNC(N)=N)=O)C(O)=O)O
Biological Activity: Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a Kd value of 5.13e-08 M) and competitive PGP-1 inhibitor (Ki = 1.2 µM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1-SFRP1 interaction, inhibits the activation of the GSK3α/β-β-catenin pathway, and reduces the upregulation of FASLG. Benarthin attenuates urothelial anoikis and reduces cell Apoptosis. Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Benarthin | 95.79% | Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a Kd value of 5.13e-08 M) and competitive PGP-1 inhibitor (Ki = 1.2 µM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1-SFRP1 interaction, inhibits the activation of the GSK3α/β-β-catenin pathway, and reduces the upregulation of FASLG. Benarthin attenuates urothelial anoikis and reduces cell Apoptosis. Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones. | ||||||||||||||||||||
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- [1]. Matsuo Y, et al. Streptobactin, a tricatechol-type siderophore from marine-derived Streptomyces sp. YM5-799. J Nat Prod. 2011;74(11):2371-2376. [Content Brief]
- [2]. Liu M, et al. FASLG Derived from Fibroblasts in Hydroxyapatite-Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure. Adv Sci (Weinh). Published online April 2, 2026. [Content Brief]
- [3]. Zhang R, et al. Carnosic acid-loaded stimuli-responsive hydrogel promotes wound healing through PGP-1 mediated immune remodeling. J Nanobiotechnology. 2026;24(1):296. Published 2026 Feb 23. [Content Brief]
Keywords
