Streptobactin, a tricatechol-type siderophore from marine-derived Streptomyces sp. YM5-799

  • J Nat Prod. 2011 Nov 28;74(11):2371-6. doi: 10.1021/np200290j.
Yoshihide Matsuo  1 ,  Kaneo Kanoh ,  Jae-Hyuk Jang ,  Kyoko Adachi ,  Satoru Matsuda ,  Osamu Miki ,  Toshiaki Kato ,  Yoshikazu Shizuri
Affiliations
  • 1. Suntory Holdings Ltd. , Yamazaki, Shimamoto, Mishima, Osaka 618-0001, Japan.
PMID: 22014204 DOI: 10.1021/np200290j
Abstract

A new catechol-type siderophore, streptobactin (1), was isolated from a culture broth of the marine-derived actinomycete Streptomyces sp. YM5-799. The structure of streptobactin was determined by NMR and MS analyses and ESIMS/MS experiments to be a cyclic trimer of benarthin. A dibenarthin (2), a tribenarthin (3), and benarthin (4) were also obtained. The production of 1 was regulated by an iron concentration in the culture. The iron-chelating activity of the compounds was evaluated by the chrome azurol sulfonate assay.

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