4910-46-7
Chemical Structure
β-Spaglumic acid
Synonym(s): β-NAAG; β-N-Acetylaspartylglutamic acid
- CAS No.: 4910-46-7
- Formula:C11H16N2O8
- Molecular Weight:304.25
IUPAC Name: ((S)-3-acetamido-3-carboxypropanoyl)-L-glutamic acid
InChIKey: GUCKKCMJTSNWCU-BQBZGAKWSA-N
SMILES: O=C(O)CC[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(C)=O)=O
Biological Activity: β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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β-Spaglumic acid | 99.97% | β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies. | ||||||||||||||||||||
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References
- [1]. Yourick DL, et al. N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures. Brain Res. 2003 Nov 21;991(1-2):56-64. [Content Brief]
- [2]. Wroblewska B, et al. β-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor. J Neurophysiol. 2001 Mar;85(3):1097-106. [Content Brief]
