1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Spaglumic Acid

Spaglumic Acid (Synonyms: NAAG; N-Acetylaspartylglutamic acid)

Cat. No.: HY-100921
Handling Instructions

Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.

For research use only. We do not sell to patients.

Spaglumic Acid Chemical Structure

Spaglumic Acid Chemical Structure

CAS No. : 3106-85-2

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Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.

IC50 & Target

Human Endogenous Metabolite


In Vitro

Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].

Molecular Weight







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