1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

Isospaglumic acid (Synonyms: N-Acetylaspartylglutamic acid; NAAG; α-Spaglumic acid)

Cat. No.: HY-100921
Handling Instructions

Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.

For research use only. We do not sell to patients.

Isospaglumic acid Chemical Structure

Isospaglumic acid Chemical Structure

CAS No. : 3106-85-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.

IC50 & Target

Human Endogenous Metabolite


In Vitro

Isospaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2868 mL 16.4339 mL 32.8677 mL
5 mM 0.6574 mL 3.2868 mL 6.5735 mL
10 mM 0.3287 mL 1.6434 mL 3.2868 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







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Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Isospaglumic acid
Cat. No.:

Isospaglumic acid

Cat. No.: HY-100921