Spaglumic acid
Based on 1 publication(s) in Google Scholar
Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 3106-85-2
- Formula: C11H16N2O8
- Molecular Weight:304.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Spaglumic acid
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
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| SK-N-SH | IC50 |
3 mM
Compound: N-acetyl-L-aspartyl-L-glutamate
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TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 10 uM) in PEPT2-expressing SK-N-SH cells
TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 10 uM) in PEPT2-expressing SK-N-SH cells
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[PMID: 9755050] |
Spaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3106-85-2
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Appearance Solid
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Molecular Weight 304.25
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Formula C11H16N2O8
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Color White to off-white
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SMILES
O=C(O)CC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC(C)=O)=O
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Synonyms
N-Acetylaspartylglutamic acid
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation. [Abstract]2026 May 6:152409. PMID: 42103119
Solvent & Solubility
H2O : 175 mg/mL (575.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (328.68 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2868 mL | 16.4339 mL | 32.8677 mL | 82.1693 mL |
| 5 mM | 0.6574 mL | 3.2868 mL | 6.5735 mL | 16.4339 mL | |
| 10 mM | 0.3287 mL | 1.6434 mL | 3.2868 mL | 8.2169 mL | |
| 15 mM | 0.2191 mL | 1.0956 mL | 2.1912 mL | 5.4780 mL | |
| 20 mM | 0.1643 mL | 0.8217 mL | 1.6434 mL | 4.1085 mL | |
| 25 mM | 0.1315 mL | 0.6574 mL | 1.3147 mL | 3.2868 mL | |
| 30 mM | 0.1096 mL | 0.5478 mL | 1.0956 mL | 2.7390 mL | |
| 40 mM | 0.0822 mL | 0.4108 mL | 0.8217 mL | 2.0542 mL | |
| 50 mM | 0.0657 mL | 0.3287 mL | 0.6574 mL | 1.6434 mL | |
| 60 mM | 0.0548 mL | 0.2739 mL | 0.5478 mL | 1.3695 mL | |
| 80 mM | 0.0411 mL | 0.2054 mL | 0.4108 mL | 1.0271 mL | |
| 100 mM | 0.0329 mL | 0.1643 mL | 0.3287 mL | 0.8217 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Spaglumic acid Related Classifications
HY-100921 Related Classifications
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