1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Isospaglumic acid

Isospaglumic acid (Synonyms: N-Acetylaspartylglutamic acid; NAAG; α-Spaglumic acid)

Cat. No.: HY-100921
Handling Instructions

Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.

For research use only. We do not sell to patients.

Isospaglumic acid Chemical Structure

Isospaglumic acid Chemical Structure

CAS No. : 3106-85-2

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Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.

IC50 & Target

Human Endogenous Metabolite


In Vitro

Isospaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].

Molecular Weight







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