2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Aminopeptidase mGluR
  4. β-Spaglumic acid

β-Spaglumic acid  (Synonyms: β-NAAG; β-N-Acetylaspartylglutamic acid)

Cat. No.: HY-130553
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β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies.

For research use only. We do not sell to patients.

β-Spaglumic acid Chemical Structure

β-Spaglumic acid Chemical Structure

CAS No. : 4910-46-7

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Based on 1 publication(s) in Google Scholar

β-Spaglumic acid Related Antibodies

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Description

β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies[1][2].

IC50 & Target

NAAG peptidase, mGluR3[1][2].
In Vitro

β-Spaglumic acid (63-1000 µM; 2 h) protects against NMDA-induced injury of spinal cord cells in a dose-dependent manner[1].
β-Spaglumic acid (0-1000 µM; 2 h) protects spinal cord cells against hypoxia[1].
β-Spaglumic acid (500 µM) significantly reduces intraneuronal free Ca2+ responses upon neuronal exposure to 25 µM NMDA[1].
β-Spaglumic acid (100 µM; 7 min) antagonizes mGluR3 in cerebellar granule cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Spaglumic acid Related Antibodies

Cell Viability Assay[1]

Cell Line: Spinal cord cells (NMDA-induced) (from spinal cords removed from prenatal day 15 Sprague-Dawley rat fetuses)
Concentration: 63-1000 µM
Incubation Time: 2 h
Result: Led to a significant attenuation of NMDA toxicity at a concentration of 63 µM and completely blocked NMDA toxicity with 500 and 1000 µM concentrations.
Apparently minimized the basal loss of cell viability associated with experimental handling of the cells (e.g. serum removal, media changes).

Cell Viability Assay[1]

Cell Line: Spinal cord cells (hypoxic-induced)
Concentration: 0-1000 µM
Incubation Time: 2 h
Result: Provided 75% protection during hypoxia when at 8 µM and completely eliminated hypoxia-induced loss of viability (107.4-114.4% protection, respectively) when at 63-1000 µM.

Cell Viability Assay[2]

Cell Line: Cerebellar granule cells (expressing group I-III mGluRs)
Concentration: 100 µM
Incubation Time: 7 min
Result: Blocked NAAG inhibition of forskolin-stimulated cAMP formation via mGluR3.
Molecular Weight

304.25

Formula

C11H16N2O8
CAS No.
SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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β-Spaglumic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Spaglumic acid4910-46-7β-NAAG β-N-Acetylaspartylglutamic acidAminopeptidasemGluRMetabotropic glutamate receptorsneuroprotectionmGluR3spinal cord cellscerebellar granule cellsInhibitorinhibitorinhibit

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