β-Spaglumic acid
Based on 1 publication(s) in Google Scholar
β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies.
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- Pureza: 99.97%
- No. CAS: 4910-46-7
- Fòrmula: C11H16N2O8
- Peso molecular:304.25
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Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) β-Spaglumic acid
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Actividad biológica
Descripciòn
IC50 & Target
In Vitro
β-Spaglumic acid (63-1000 µM; 2 h) protects against NMDA-induced injury of spinal cord cells in a dose-dependent manner[1].
β-Spaglumic acid (0-1000 µM; 2 h) protects spinal cord cells against hypoxia[1].
β-Spaglumic acid (500 µM) significantly reduces intraneuronal free Ca2+ responses upon neuronal exposure to 25 µM NMDA[1].
β-Spaglumic acid (100 µM; 7 min) antagonizes mGluR3 in cerebellar granule cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Spinal cord cells (NMDA-induced) (from spinal cords removed from prenatal day 15 Sprague-Dawley rat fetuses)
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Concentration:63-1000 µM
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Incubation Time:2 h
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Result:Led to a significant attenuation of NMDA toxicity at a concentration of 63 µM and completely blocked NMDA toxicity with 500 and 1000 µM concentrations.
Apparently minimized the basal loss of cell viability associated with experimental handling of the cells (e.g. serum removal, media changes).
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Cell Line:Spinal cord cells (hypoxic-induced)
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Concentration:0-1000 µM
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Incubation Time:2 h
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Result:Provided 75% protection during hypoxia when at 8 µM and completely eliminated hypoxia-induced loss of viability (107.4-114.4% protection, respectively) when at 63-1000 µM.
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Cell Line:Cerebellar granule cells (expressing group I-III mGluRs)
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Concentration:100 µM
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Incubation Time:7 min
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Result:Blocked NAAG inhibition of forskolin-stimulated cAMP formation via mGluR3.
Chemical Information
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No. CAS 4910-46-7
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Appearance Oil
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Peso molecular 304.25
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Fòrmula C11H16N2O8
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Color Colorless to off-white
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SMILES
O=C(O)CC[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(C)=O)=O
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Synonyms
β-NAAG; β-N-Acetylaspartylglutamic acid
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
In Vitro:
H2O : ≥ 100 mg/mL (328.68 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Yourick DL, et al. N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures. Brain Res. 2003 Nov 21;991(1-2):56-64. [Content Brief]
[2]. Wroblewska B, et al. β-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor. J Neurophysiol. 2001 Mar;85(3):1097-106. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2868 mL | 16.4339 mL | 32.8677 mL | 82.1693 mL |
| 5 mM | 0.6574 mL | 3.2868 mL | 6.5735 mL | 16.4339 mL | |
| 10 mM | 0.3287 mL | 1.6434 mL | 3.2868 mL | 8.2169 mL | |
| 15 mM | 0.2191 mL | 1.0956 mL | 2.1912 mL | 5.4780 mL | |
| 20 mM | 0.1643 mL | 0.8217 mL | 1.6434 mL | 4.1085 mL | |
| 25 mM | 0.1315 mL | 0.6574 mL | 1.3147 mL | 3.2868 mL | |
| 30 mM | 0.1096 mL | 0.5478 mL | 1.0956 mL | 2.7390 mL | |
| 40 mM | 0.0822 mL | 0.4108 mL | 0.8217 mL | 2.0542 mL | |
| 50 mM | 0.0657 mL | 0.3287 mL | 0.6574 mL | 1.6434 mL | |
| 60 mM | 0.0548 mL | 0.2739 mL | 0.5478 mL | 1.3695 mL | |
| 80 mM | 0.0411 mL | 0.2054 mL | 0.4108 mL | 1.0271 mL | |
| 100 mM | 0.0329 mL | 0.1643 mL | 0.3287 mL | 0.8217 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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