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Aminopeptidase Related Products (114)
Related Products (114)
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Actinonin
0 ImagesSynonyms: (-)-ActinoninActinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities.
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Tosedostat
0 ImagesSynonyms: CHR-2797Tosedostat (CHR-2797) is an orally active aminopeptidase inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines.
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ERAP1-IN-1
0 ImagesERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates.
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TNP-470
0 ImagesSynonyms: AGM-1470TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.
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Amastatin hydrochloride
0 ImagesAmastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with Ki values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase.
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ERAP1-IN-4
0 ImagesCat. No.: HY-183267ERAP1-IN-4 is an orally acvtive endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor with a pIC50 of 7.9 and an LLE of 5.3. ERAP1-IN-4 inhibits hydrolysis of peptide substrates by ERAP1, with high activity against Allotype1 and Allotype2. ERAP1-IN-4 reduced efficacy against other allotypes, and modulates ERAP1-mediated peptide processing to inhibit antigenic epitope presentation. ERAP1-IN-4 can be used for the research of cancer[1].
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H-Ala-Pro-Ala-OH
0 ImagesCat. No.: HY-W794670CAS No.: 61430-14-6H-Ala-Pro-Ala-OH, tripeptide, is a substrate for Escherichia coli PepP (Xaa-Pro aminopeptidase). H-Ala-Pro-Ala-OH acts as a nitrogen source for wild-type Escherichia coli.
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Met-AMC
0 ImagesCat. No.: HY-184777CAS No.: 94367-34-7Met-AMC is a fluorescent substrate used to detect the activity of methionine aminopeptidase (MetAP). Hydrolysis of the substrate releases the fluorophore AMC, with detection performed at an excitation wavelength of 360 nm and an emission wavelength of 460 nm. Met-AMC can distinguish the effects of different metal cofactors on the substrate preference of MetAP1: Zn (II)-MetAP1 barely hydrolyzes Met-AMC, while Co (II)-, Mn (II)-, and Ni (II)-MetAP1 can stably cleave this substrate. Met-AMC can be used to establish an intracellular MetAP activity cell-based assay system, which quantifies the intracellular MetAP inhibition level by monitoring the fluorescence signal from substrate hydrolysis in living cells.
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Firibastat
0 ImagesSynonyms: QGC001; RB150Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (Ki=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.
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β-Spaglumic acid
0 ImagesSynonyms: β-NAAG; β-N-Acetylaspartylglutamic acidβ-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies.
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Acebilustat
0 ImagesSynonyms: CTX-4430Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory agent.
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L-Leucinol
0 ImagesSynonyms: (+)-LeucinolL-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with a Ki value of 17 μM. As a dietary intake inhibitor, L-Leucinol reduces the basal dietary leucine intake in rats via microinjection into the rat anterior piriform cortex.
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L-Leucyl-4-nitroanilide
0 ImagesL-Leucyl-4-nitroanilide is a chromogenic substrate suitable for activity assays of leucine aminopeptidase, and it can be used in studies related to the enzymatic properties of aminopeptidases.
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Aminopeptidase-IN-1
0 ImagesAminopeptidase-IN-1 is an insulin-regulated aminopeptidase (IRAP) inhibitor with an Ki value of 7.7 μM. Aminopeptidase-IN-1 can be used for the research of memory impairments.
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ERAP2-IN-1
0 ImagesERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC50 of 27 μM and model peptide hydrolysis with an IC50 of 44 μM.
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Apstatin TFA
0 ImagesCat. No.: HY-128090APurity: 99.57%Apstatin TFA is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin TFA shows cardioprotection.
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HFI-142
0 ImagesHFI-142 is an insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 2.01 μM.
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ERAP1 modulator-2
0 ImagesERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of <100 nM.
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HFI-437
0 ImagesHFI-437 is a potent non-peptidic insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 20 nM. HFI-437 is a cognitive enhancer.
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ARM1
0 ImagesSynonyms: 4BSAARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC50 7.61 µM and epoxide hydrolase inhibitory activity with an IC50 12.4 µM.
