1. JAK/STAT Signaling
    Stem Cell/Wnt
    Apoptosis
    TGF-beta/Smad
  2. STAT
    Apoptosis
    TGF-beta/Smad
  3. Alantolactone

Alantolactone (Synonyms: (+)-Alantolactone; Alant camphor; Inula camphor)

Cat. No.: HY-N0038 Purity: 99.94%
Handling Instructions

Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer.

For research use only. We do not sell to patients.

Alantolactone Chemical Structure

Alantolactone Chemical Structure

CAS No. : 546-43-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
25 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 336 In-stock
Estimated Time of Arrival: December 31
100 mg USD 540 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Alantolactone purchased from MCE. Usage Cited in: Stem Cells. 2019 Feb;37(2):190-201.

    Western blot images show Smad2/3 phosphorylation is lower than baseline in the sh-GPM6B cells and higher than baseline in the GPM6B-sgRNA cells. The phosphorylation of Smad2/3 in the sh-GPM6B TGF-β1 group is elevated by Alantolactone and the phosphorylation is reduced by treatment with SB431542.

    Alantolactone purchased from MCE. Usage Cited in: Stem Cells. 2019 Feb;37(2):190-201.

    Western blot analyses show the repression of SMC specific markers in the sh-GPM6B TGF-β1 group are abolished by Alantolactone in the sh-GPM6B and the enrichment of SMC specific markers in the GPM6B-sgRNA cells is cancelled by treatment with SB431542.

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    Description

    Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer[1][2][3].

    IC50 & Target

    STAT3

     

    In Vitro

    Alantolactone induces apoptosis in HepG2 cells in a dose-dependent manner. This Alantolactone-induced apoptosis is found to be associated with GSH depletion, inhibition of STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, and increased Bax/Bcl-2 ratio and caspase-3 activation[1]. Alantolactone decreases STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases[2].
    Alantolactone induces activin/SMAD3 signaling in human colon adenocarcinoma HCT-8 cells. Alantolactone performs its antitumor effect by interrupting the interaction between Cripto-1 and the activin receptor type IIA in the activin signaling pathway[4].
    Alantolactone (5 μg/mL, 24 h) inhibits cell proliferation in colon adenocarcinoma HCT-8 cells[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[4]

    Cell Line: HCT-8 cells.
    Concentration: 5 μg/mL (~21.6 μM).
    Incubation Time: 24 h.
    Result: Activated the activin signaling pathway in HCT-8 cells.
    In Vivo

    It is found that the average tumor volume in the Alantolactone-treated mice is approximately 2.17-fold lower compared with that in the control mice. However the administration of Alantolactone does not affect the overall bodyweight during the experimental period, suggesting no apparent toxicity. Additionally, the average tumor weight is significantly lower in the Alantolactone-treated mice compared with the control mice. What’s more, the administration of Alantolactone results in a significant decrease in p-STAT3 and cyclin D1 expression in the tumor tissues[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female athymic BALB/c nude mice at the age of 6 weeks[2].
    Dosage: 2.5 mg/kg.
    Administration: I.P. injection every 2 days.
    Result: Exhibited anti-cancer activity.
    Molecular Weight

    232.32

    Formula

    C₁₅H₂₀O₂

    CAS No.

    546-43-0

    SMILES

    O=C(O[[email protected]@]1([H])[[email protected]]2([H])C=C3[[email protected]@H](C)CCC[[email protected]]3(C)C1)C2=C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (430.44 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3044 mL 21.5220 mL 43.0441 mL
    5 mM 0.8609 mL 4.3044 mL 8.6088 mL
    10 mM 0.4304 mL 2.1522 mL 4.3044 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    Alantolactone(+)-Alantolactone Alant camphor Inula camphorSTATApoptosisTGF-beta/SmadTransforming growth factor betaInhibitorinhibitorinhibit

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