1. Terpenoids and Glycosides
  2. Dehydrocostus Lactone

Dehydrocostus Lactone (Synonyms: (-)-Dehydrocostus lactone; Epiligulyl oxide)

Cat. No.: HY-N0591 Purity: 99.42%
Handling Instructions

Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa.

For research use only. We do not sell to patients.

Dehydrocostus Lactone Chemical Structure

Dehydrocostus Lactone Chemical Structure

CAS No. : 477-43-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 92 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 156 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa. IC50 value: Target: In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. In vivo: Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo [3].

Molecular Weight

230.30

Formula

C₁₅H₁₈O₂

CAS No.
SMILES

O=C(O[[email protected]@]([[email protected]@]1([H])C(CC[[email protected]@]21[H])=C)([H])[[email protected]@]3([H])CCC2=C)C3=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1085.54 mM; Need ultrasonic)

Ethanol : 15 mg/mL (65.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3422 mL 21.7108 mL 43.4216 mL
5 mM 0.8684 mL 4.3422 mL 8.6843 mL
10 mM 0.4342 mL 2.1711 mL 4.3422 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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Keywords:

Dehydrocostus Lactone(-)-Dehydrocostus lactone Epiligulyl oxideOthersInhibitorinhibitorinhibit

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Product Name:
Dehydrocostus Lactone
Cat. No.:
HY-N0591
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