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Cat. No.: HY-P99720

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Biologically Validated

Luspatercept

(Synonyms: ACE-536; luspatercept–aamt)

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.

For research use only. We do not sell to patients.

Purity: 98.92%
CAS No.: 1373715-00-4
Molecular Weight:75.71 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Luspatercept Chemical Structure

CAS No.: 1373715-00-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Publications (5)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All TGF-beta/Smad Isoforms :

Smad1
Smad3

In Vitro

Luspatercept (0.1-1000 ng/mL) inhibits Smad2 and Smad 3 signaling induced by GDF11 and GDF8 in A204 cells^[1].
Luspatercept binds with GDF11, GDF8, activin B, BMP10 and BMP6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Luspatercept (0.1-60 mg/kg, s.c.; 10 mg/kg, i.v.; twice weekly for 8 weeks) increases red blood cell (RBC) count, hemoglobin levels and hematocrit in mice, rats and monkeys^[1].
Luspatercept (10 mg/kg; s.c., once) reduces erythroid burst forming units (BFU-Es) and erythroid colony-forming units (CFU-Es) from bone marrow and spleen of C57BL/6 mice^[1].
Luspatercept (10 mg/kg; i.p., once) inhibits Smad2/3 phosphorylation in mouse spleen^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice^[1]
Dosage:

0.1, 0.3, 1, 3 and 10 mg/kg
Administration:

Subcutaneous injection and intravenous injection; 0.1-10 mg/kg (C57BL/6 mice, s.c.), 6-60 mg/kg (Sprague Dawley rats, s.c.), 0.4-30 mg/kg (cynomolgus monkeys, s.c.), 10 mg/kg, (cynomolgus monkeys, i.v.); twice weekly for 8 weeks
Result:

Dose-dependently increased the level of RBC, hemoglobin and hematocrit in mice, rats and monkeys.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

[ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2-IGHG1 Fc (Fragment constant)

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized HY-P72632 GDF-8 Protein, Human/Mouse/Rat (HEK293) can bind Luspatercept. The EC₅₀ for this effect is 74.63 ng/mL.
Immobilized HY-P70222Y GDF-11/BMP-11 Protein, Human (HEK293, solution) can bind Luspatercept. The EC₅₀ for this effect is 99.57 ng/mL.
Immobilized Recombinant Anti-ACVR2B Antibody can bind Luspatercept. The EC₅₀ for this effect is 3.08 ng/mL.

Chemical Information

CAS No. 1373715-00-4
Appearance Liquid
Molecular Weight 75.71 kDa
Color Colorless to light yellow
SMILES

[Luspatercept]
Synonyms

ACE-536; luspatercept–aamt
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Journal Impact Factor

Science

A glutamine metabolic switch supports erythropoiesis. [Abstract]

2024 Nov 15;386(6723):eadh9215. PMID: 39541460
J Extracell Vesicles

Umbilical Cord-Mesenchymal Stromal Cell-Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non-Alcoholic Fatty Liver Disease. [Abstract]

2025 Jul;14(7):e70125. PMID: 40620065
Blood Adv

UBE2O AS A KEY REGULATOR OF DRUG-INDUCED ERYTHROPOIESIS IN THE CONTEXT OF MYELODYSPLASTIC SYNDROMES. [Abstract]

2025 Nov 5:bloodadvances.2025017340. PMID: 41191526
Sci Rep

Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control. [Abstract]

2025 Jun 6;15(1):19887. PMID: 40481031
Mol Carcinog

TGFβ-Mediated Overexpression of Podoplanin Serves as a Potential Diagnostic Biomarker in Acute Promyelocytic Leukemia. [Abstract]

2026 Feb 12. PMID: 41684157

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Suragani RN, et al. Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis. Nat Med. 2014 Apr;20(4):408-14. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Publications (5)
Purity & Documentation
References

1/16

[ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2-IGHG1 Fc (Fragment constant)
1/16

Immobilized HY-P72632 GDF-8 Protein, Human/Mouse/Rat (HEK293) can bind Luspatercept. The EC₅₀ for this effect is 74.63 ng/mL.
1/16

Immobilized HY-P70222Y GDF-11/BMP-11 Protein, Human (HEK293, solution) can bind Luspatercept. The EC₅₀ for this effect is 99.57 ng/mL.
1/16

Immobilized Recombinant Anti-ACVR2B Antibody can bind Luspatercept. The EC₅₀ for this effect is 3.08 ng/mL.
1/16

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Luspatercept

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Luspatercept

All TGF-beta/Smad Isoforms

Biological Activity

Chemical Information

Publications (5)

Purity & Documentation

References

Calculators

Help & FAQs

Luspatercept

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Luspatercept

All TGF-beta/Smad Isoforms

Biological Activity

Chemical Information

Publications (5)

Purity & Documentation

References

Calculators

Help & FAQs

Luspatercept Related Classifications

Cat. No.: HY-P99720