2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Luspatercept

Luspatercept  (Synonyms: ACE-536; luspatercept–aamt)

Cat. No.: HY-P99720 Purity: 98.92%
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Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.

For research use only. We do not sell to patients.

Luspatercept Chemical Structure

Luspatercept Chemical Structure

CAS No. : 1373715-00-4

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Luspatercept Related Antibodies

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Description

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia[1].

In Vitro

Luspatercept (0.1-1000 ng/mL) inhibits Smad2 and Smad 3 signaling induced by GDF11 and GDF8 in A204 cells[1].
Luspatercept binds with GDF11, GDF8, activin B, BMP10 and BMP6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Luspatercept Related Antibodies
In Vivo

Luspatercept (0.1-60 mg/kg, s.c.; 10 mg/kg, i.v.; twice weekly for 8 weeks) increases red blood cell (RBC) count, hemoglobin levels and hematocrit in mice, rats and monkeys[1].
Luspatercept (10 mg/kg; s.c., once) reduces erythroid burst forming units (BFU-Es) and erythroid colony-forming units (CFU-Es) from bone marrow and spleen of C57BL/6 mice[1].
Luspatercept (10 mg/kg; i.p., once) inhibits Smad2/3 phosphorylation in mouse spleen[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 0.1, 0.3, 1, 3 and 10 mg/kg
Administration: Subcutaneous injection and intravenous injection; 0.1-10 mg/kg (C57BL/6 mice, s.c.), 6-60 mg/kg (Sprague Dawley rats, s.c.), 0.4-30 mg/kg (cynomolgus monkeys, s.c.), 10 mg/kg, (cynomolgus monkeys, i.v.); twice weekly for 8 weeks
Result: Dose-dependently increased the level of RBC, hemoglobin and hematocrit in mice, rats and monkeys.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Luspatercept]
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Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.92%

COA (231 KB)

Handling Instructions (2659 KB)
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Luspatercept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luspatercept1373715-00-4ACE-536 luspatercept–aamtACE536ACE 536TGF-beta/SmadTransforming growth factor betafusion proteinerythrocyteerythroid precursoranemiaBFU-ECFU-EmiceInhibitorinhibitorinhibit

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