2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Kartogenin sodium

Kartogenin sodium  (Synonyms: KGN sodium)

Cat. No.: HY-16268A Purity: 99.84%
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Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research.

For research use only. We do not sell to patients.

CAS No. : 1401168-39-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Customer Review

Based on 31 publication(s) in Google Scholar

Other Forms of Kartogenin sodium:

Kartogenin sodium Related Antibodies

Top Publications Citing Use of Products

    Kartogenin sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Sep 21;9(24):7108-7121.   [Abstract]

    CSPC were isolated from cartilage and treated with vehicle or 10 μM Kartogenin (KGN), 4-ABP or phthalic acid (PA) in the chondrogenic differentiation medium. Aggrecan, Sox9 and type II collagen mRNA expression levels (determined by RT-qPCR) at day 21.

    Kartogenin sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Sep 21;9(24):7108-7121.   [Abstract]

    p-ERK1/2, p-AKT, p-JUN, p-RSK-3 and CDK-2 protein expression in UC-MSC treated with vehicle, Kartogenin (KGN) or 4-ABP (10 μM) for 3 days.

    Kartogenin sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Sep 21;9(24):7108-7121.   [Abstract]

    Oral Kartogenin (KGN) (2.5, 5 mg/kg) administration schedule in destabilization of medial meniscus (DMM)-induced osteoarthritis in STR/Ort mice. Representative images of toluidine blue and immunohistochemical staining of type II collagen and MMP-13 in articular cartilage.

    • Biological Activity

    • Purity & Documentation

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    • Customer Review

    Description

    Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research[1][2][3][4].

    In Vitro

    Kartogenin sodium (100 nM; 72 h) induces chondrocyte nodule formation in primary hMSCs[1].
    Kartogenin sodium (10 nM-10 μM; 72 h) increases chondrocyte-specific gene expression in hMSCs[1].
    Kartogenin sodium (0.12-10 μM; 48 h) inhibits nitric oxide (NO) and glycosaminoglycan (GAG) release induced by cytokines in primary bovine articular chondrocytes[1].
    Kartogenin sodium (50-5000 nM; 2 weeks) induces the chondrogenetic differentiation of the BMSCs in a concentration-dependent manner[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Kartogenin sodium Related Antibodies
    In Vivo

    Kartogenin sodium (10 μM in 4 μL of saline; i.a. on days 7 and 21) promotes cartilag erepair in collagenase VII-induced OA models in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    339.32

    Formula

    C20H14NNaO3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (294.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9471 mL 14.7354 mL 29.4707 mL
    5 mM 0.5894 mL 2.9471 mL 5.8941 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.84%

    SDS (252 KB)

    COA (251 KB) HNMR (237 KB) LCMS (112 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9471 mL 14.7354 mL 29.4707 mL 73.6768 mL
    5 mM 0.5894 mL 2.9471 mL 5.8941 mL 14.7354 mL
    10 mM 0.2947 mL 1.4735 mL 2.9471 mL 7.3677 mL
    15 mM 0.1965 mL 0.9824 mL 1.9647 mL 4.9118 mL
    20 mM 0.1474 mL 0.7368 mL 1.4735 mL 3.6838 mL
    25 mM 0.1179 mL 0.5894 mL 1.1788 mL 2.9471 mL
    30 mM 0.0982 mL 0.4912 mL 0.9824 mL 2.4559 mL
    40 mM 0.0737 mL 0.3684 mL 0.7368 mL 1.8419 mL
    50 mM 0.0589 mL 0.2947 mL 0.5894 mL 1.4735 mL
    60 mM 0.0491 mL 0.2456 mL 0.4912 mL 1.2279 mL
    80 mM 0.0368 mL 0.1842 mL 0.3684 mL 0.9210 mL
    100 mM 0.0295 mL 0.1474 mL 0.2947 mL 0.7368 mL
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    Kartogenin sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Kartogenin1401168-39-5KGNTGF-beta/SmadTransforming growth factor betaInhibitorinhibitorinhibit

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