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Kartogenin sodium

(Synonyms: KGN sodium)
33 Cited Publications
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Based on 33 publication(s) in Google Scholar

Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research.

For research use only. We do not sell to patients.

  • Purity: 99.84%
  • CAS No.: 1401168-39-5
  • Formula: C20H14NNaO3
  • Molecular Weight:339.32
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • Kartogenin sodium Chemical Structure
    Kartogenin sodium Chemical Structure
  • Experimental Validation Results for Kartogenin sodium
  • Experimental Validation Results for Kartogenin sodium
  • Experimental Validation Results for Kartogenin sodium
CAS No.: 1401168-39-5
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  • Kartogenin sodium Chemical Structure
    Kartogenin sodium Chemical Structure
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    Kartogenin sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Sep 21;9(24):7108-7121.  [Abstract]

    Customer Validation
     CSPC were isolated from cartilage and treated with vehicle or 10 μM Kartogenin (KGN), 4-ABP or phthalic acid (PA) in the chondrogenic differentiation medium. Aggrecan, Sox9 and type II collagen mRNA expression levels (determined by RT-qPCR) at day 21.

  • 1/16

    Kartogenin sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Sep 21;9(24):7108-7121.  [Abstract]

    Customer Validation
     p-ERK1/2, p-AKT, p-JUN, p-RSK-3 and CDK-2 protein expression in UC-MSC treated with vehicle, Kartogenin (KGN) or 4-ABP (10 μM) for 3 days.

  • 1/16

    Kartogenin sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Sep 21;9(24):7108-7121.  [Abstract]

    Customer Validation
     Oral Kartogenin (KGN) (2.5, 5 mg/kg) administration schedule in destabilization of medial meniscus (DMM)-induced osteoarthritis in STR/Ort mice. Representative images of toluidine blue and immunohistochemical staining of type II collagen and MMP-13 in articular cartilage.

  • Kartogenin sodium