Imidazoline Receptor Ligand
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I2-IRs ligand-1
0 ImagesCat. No.: HY-170994I2-IRs ligand-1 (Compound 12d) is an orally active and BBB-penetrable compound. I2-IRs ligand-1 has a high affinity for imidazoline I2 receptors (I2-IRs) (pKi: 9.98). I2-IRs ligand-1 can improve cognitive impairment in senescent mice and exhibits analgesic, anti-inflammatory, and neuroprotective activities. I2-IRs ligand-1 can be used for the research of Alzheimer's disease and related pain disorders.
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N-(2-Chloro-4-iodophenyl)-2-methyl-3,4-dihydro-2H-pyrrol-5-amine
0 ImagesCat. No.: HY-188067CAS No.: 497180-72-0LNP-911 is a ligand for the I1 imidazoline receptor. LNP-911 allosterically modulates I1Rs and enhances the effect of agonists on Forskolin (HY-15371)-stimulated cAMP accumulation. LNP-911 exists mainly as a stable imine tautomer. After radioiodination, LNP-911 serves as a selective high-affinity radioligand for characterization studies of I1Rs in membrane preparations. LNP-911 can be used in hypertension-related research.
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Metrazoline
0 ImagesCat. No.: HY-W714108CAS No.: 221225-04-3Synonyms: o-Methyl-tracizolineMetrazoline (o-Methyl-tracizoline) is the ligand for adrenergic receptor (low affinity) and imidazoline I2 receptor.
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LNP 509
0 ImagesCat. No.: HY-188065CAS No.: 773839-36-4LNP 509 is a selective I1 imidazoline receptor ligand with a bovine pKi value of 6.27. LNP 509 exists mainly in the form of a more stable imine tautomer. Intracisternal administration of LNP 509 in anesthetized rabbits induces a dose-dependent decrease in mean arterial blood pressure. LNP 509 can be used in hypertension-related research.
