773839-36-4
773839-36-4
Chemical Structure
LNP 509
- CAS 番号: 773839-36-4
- Formula:C13H22N2
- Molecular Weight:206.33
InChIKey: MMBBLZBWERBHTI-UHFFFAOYSA-N
SMILES: CC1CC(NC(C2CC2)C3CC3)=NC1C
Biological Activity: LNP 509 is a selective I1 imidazoline receptor ligand with a bovine pKi value of 6.27. LNP 509 exists mainly in the form of a more stable imine tautomer. Intracisternal administration of LNP 509 in anesthetized rabbits induces a dose-dependent decrease in mean arterial blood pressure. LNP 509 can be used in hypertension-related research[1][2].
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LNP 509 | LNP 509 is a selective I1 imidazoline receptor ligand with a bovine pKi value of 6.27. LNP 509 exists mainly in the form of a more stable imine tautomer. Intracisternal administration of LNP 509 in anesthetized rabbits induces a dose-dependent decrease in mean arterial blood pressure. LNP 509 can be used in hypertension-related research. | |||||||||||||||||||||
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References
- [1]. Schann S, et al. Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity. Journal of medicinal chemistry. 2001 May 10;44(10):1588-93.
- [2]. Remko M, et al. Theoretical study of structure, pKa, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensives. Bioorganic & medicinal chemistry. 2006 Mar 15;14(6):1715-28.
Keywords
