1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
    Imidazoline Receptor
  3. Idazoxan hydrochloride

Idazoxan hydrochloride (Synonyms: RX 781094 hydrochloride)

Cat. No.: HY-14561A
Handling Instructions

Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism.

For research use only. We do not sell to patients.

Idazoxan hydrochloride Chemical Structure

Idazoxan hydrochloride Chemical Structure

CAS No. : 79944-56-2

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Description

Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2].

IC50 & Target

α2-adrenoceptor[1]; Imidazoline receptors (IRs)[2]

In Vivo

Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1].

Animal Model: Male CD-COBS rats injected with 1 mg/kg haloperidol[1]
Dosage: 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg
Administration: Subcutaneous injection; for 1 hour
Result: Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25 mg/kg.
Molecular Weight

240.69

Formula

C₁₁H₁₃ClN₂O₂

CAS No.

79944-56-2

SMILES

[H]Cl.C1(C2OC3=CC=CC=C3OC2)=NCCN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IdazoxanRX 781094RX781094RX-781094Adrenergic ReceptorImidazoline ReceptorBeta ReceptorInhibitorinhibitorinhibit

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Idazoxan hydrochloride
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