1. GPCR/G Protein
    Neuronal Signaling
    Apoptosis
    Autophagy
  2. Imidazoline Receptor
    Adrenergic Receptor
    Apoptosis
    Autophagy
  3. Rilmenidine hemifumarate

Rilmenidine hemifumarate 

Cat. No.: HY-100490A Purity: >98.0%
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Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .

For research use only. We do not sell to patients.

Rilmenidine hemifumarate Chemical Structure

Rilmenidine hemifumarate Chemical Structure

CAS No. : 207572-68-7

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5 mg USD 375 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3].

In Vitro

Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors[1].
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: K562 cells
Concentration: 25, 50, 100 μM
Incubation Time: 24 hours
Result: Dose-dependently inhibited K562 colony formation.
In Vivo

Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[3].
Rilmenidine decreases levels of mutant huntingtin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

238.28

Formula

C₁₀H₁₆N₂O.₁/₂C₄H₄O₄

CAS No.

207572-68-7

SMILES

O=C(O)/C=C/C(O)=O.C1(NC(C2CC2)C3CC3)=NCCO1.[0.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >98.0%

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Keywords:

Rilmenidine hemifumarateImidazoline ReceptorAdrenergic ReceptorApoptosisAutophagyBeta ReceptorproliferationantihypertensiveproapoptoticmitochondrialleukemicK562cellsInhibitorinhibitorinhibit

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Rilmenidine hemifumarate
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HY-100490A
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