Harmane hydrochloride

Harmane hydrochloride also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively^[1].
The IC₅₀ of Harmane hydrochloride for benzodiazepine receptor flunitrazepam is 7 μM, the IC₅₀ for the opioid receptor is 2.8 μM, and in the presence of 50 mM sodium ions, the IC₅₀ for the opioid receptor is 42 μM, and the IC₅₀ for spiropyrinol and serotonin is 163, 101 μM^[1].
The IC₅₀ of Harmane hydrochloride for I1 imidazoline receptor is 30 nM), and the IC₅₀ for α2-adrenergic receptor is 18 μM^[2].
Harmane hydrochloride (1 μM) increases the mutagenicity of AAF to Salmonella typhimurium TA98 by three times in the presence of an S-9 mixture (containing 4 μM NADH and NADPH per ml but no NADP); in the absence of S-9, it increases the mutagenicity of N-acetyloxy AAF by 2.5 times^[4].
Harmane hydrochloride (5-25 μM, 0-72 h) reduced the dopamine content in PC12 cells (IC₅₀ is 21.2 μM) in a concentration-dependent manner and could reduce the dopamine content induces by L-DOPA^[6].
Harmane hydrochloride (20 μM, 0-72 h) inhibits the activity of tyrosine hydroxylase (TH) in PC12 cells at 24 h and restores it to normal levels at 72 h; it inhibits the expression of TH mRNA at 6 h and restores it at 48 h^[6].
Harmane hydrochloride (20μM, 30min) reduces the intracellular cyclic AMP level and intracellular calcium ion concentration in PC12 cells^[6].
Harmane hydrochloride (80-150μM, 24-48h) exhibits cytotoxicity and induces cell death^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.