1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
    Imidazoline Receptor
  3. Efaroxan hydrochloride

Efaroxan hydrochloride 

Cat. No.: HY-B1416A
Handling Instructions

Efaroxan hydrochloride is a potent and selective α2-adrenoceptor antagonist, antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist and can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Efaroxan hydrochloride Chemical Structure

Efaroxan hydrochloride Chemical Structure

CAS No. : 89197-00-2

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Description

Efaroxan hydrochloride is a potent and selective α2-adrenoceptor antagonist, antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist and can be used for the research of cardiovascular disease[1][2][3].

IC50 & Target

α2-adrenoceptor, I1-Imidazoline receptor[1][2]

In Vitro

Efaroxan hydrochloride binds to I1-imidazoline and α2-adrenergic receptors in bovine rostral ventrolateral medulla membranes, with Kis of 0.15 and 5.6 nM, respectively[1]

In Vivo

Efaroxan hydrochloride increases plasma insulin levels in both conscious fed[3].

Animal Model: Male Sprague-Dawley rats (weight range 250-300g)[3]
Dosage: 1 mg/kg, 5 mg/kg
Administration: Oral administration
Result: Significant increase in plasma insulin levels of starved rats 15 and 30 min after treatment.
Molecular Weight

252.74

Formula

C₁₃H₁₇ClN₂O

CAS No.

89197-00-2

SMILES

CCC1(C2=NCCN2)OC3=CC=CC=C3C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

EfaroxanAdrenergic ReceptorImidazoline ReceptorBeta Receptorglucose homeostasisimidazolinehypoglycaemicinsulinInhibitorinhibitorinhibit

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Efaroxan hydrochloride
Cat. No.:
HY-B1416A
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