Efaroxan

Cat. No.: HY-B1416: Data Sheet Handling Instructions
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Efaroxan is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan is a selective I1-Imidazoline receptor antagonist. Efaroxan can be used for the research of cardiovascular disease.

For research use only. We do not sell to patients.

Efaroxan Chemical Structure

CAS No. : 89197-32-0

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Efaroxan:

Efaroxan hydrochloride

Other Forms of Efaroxan:

Efaroxan hydrochloride In-stock

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

α2-adrenoceptor, I1-Imidazoline receptor^[1]^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	>300 μM Compound: Efaroxan	Antiproliferative activity against human K562 cells assessed as inhibition of cell survival after 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell survival after 48 hrs by MTT assay	[PMID: 27265687]
K562	IC₅₀	300 μM Compound: Efaroxan	Antiproliferative activity against human K562 cells assessed as inhibition of cell survival after 48 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell survival after 48 hrs by MTT assay	[PMID: 27265687]

Molecular Weight

216.28

Formula

C₁₃H₁₆N₂O

CAS No.

89197-32-0

SMILES

CCC1(C2=NCCN2)OC3=CC=CC=C3C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Berridge TL, et al. Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat. Eur J Pharmacol. 1992 Mar 24;213(2):205-12. [Content Brief]

[2]. A O Abdel-Zaher, et al. The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists. Pharmacol Res. 2001 Nov;44(5):397-409. [Content Brief]

[3]. T L Berridge, et al. Comparison of the effects of efaroxan and glibenclamide on plasma glucose and insulin levels in rats. Eur J Pharmacol. 1992 Mar 24;213(2):213-8. [Content Brief]

Efaroxan Related Classifications

Metabolic Disease Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efaroxan89197-32-0Adrenergic ReceptorImidazoline ReceptorBeta Receptorglucose homeostasisimidazolinehypoglycaemicinsulinInhibitorinhibitorinhibit

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