Wnt-C59 (Synonyms: C59)

Cat. No.: HY-15659G: FAQs
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Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659). Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC₅₀ of 74 pM.

For research use only. We do not sell to patients.

Wnt-C59 Chemical Structure

CAS No. : 1243243-89-1

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Wnt-C59

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Description	Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659). Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC₅₀ of 74 pM.
IC₅₀ & Target	IC50: 74 pM (PORCN)^[1]
Molecular Weight	379.45
Formula	C₂₅H₂₁N₃O
CAS No.	1243243-89-1
SMILES	O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. [Content Brief] [2]. Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6(16):14428-39. [Content Brief]

Wnt-C59 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Wnt-C59 (GMP)1243243-89-1C59 (GMP)WntPorcupineInhibitorinhibitorinhibit

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Wnt-C59 (Synonyms: C59)

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