2490686-86-5
2490686-86-5
Chemical Structure
WHN-88
- CAS No.: 2490686-86-5
- Formula:C18H13I2N3O2
- Molecular Weight:557.12
InChIKey: FVIRMZFNQACNJW-UHFFFAOYSA-N
SMILES: O=C(CN1C=C(I)C(C(I)=C1)=O)NC2=NC=C(C3=CC=CC=C3)C=C2
Biological Activity:
WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/β-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice[1].
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WHN-88 | WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/β-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice. |
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