GNF-6231 (Standard)
GNF-6231 (Standard) is the analytical standard of GNF-6231 (HY-100408). This product is intended for research and analytical applications. GNF-6231 is a porcupine (IC50= 0.8 nM), Pron, and endoplasmic reticulum protein inhibitor with oral activity. GNF-6231 has anticancer activity. GNF-6231 can prevent the activation of the Wnt pathway by blocking the secretion of all Wnt ligands. GNF-6231 can be used in the study of myocardial infarction.
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- No. CAS: 1243245-18-2
- Fòrmula: C24H25FN6O2
- Peso molecular:448.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
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HY-17545
LGK974PORCN Inhibitor -
HY-15659
Wnt-C59PORCN Inhibitor -
HY-100408
GNF-6231Porcupine Inhibitor -
HY-15825
IWP L6Porcn Inhibitor -
HY-18988
ETC-159PORCN Inhibitor -
HY-111472
Porcn-IN-1Porcupine Inhibitor -
HY-13912
IWP-2Wnt Production Inhibitor -
HY-15659R
Wnt-C59 (Standard)PORCN Inhibitor -
HY-12238
IWR-1Wnt Signaling Inhibitor -
HY-100853
IWP-O1Porcn Inhibitor -
HY-15659G
Wnt-C59 (GMP)PORCN Inhibitor -
HY-15825G
IWP L6 (GMP)Porcn Inhibitor
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 1243245-18-2
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Peso molecular 448.49
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Fòrmula C24H25FN6O2
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SMILES
O=C(NC1=NC=C(N2CCN(C(C)=O)CC2)C=C1)CC3=CN=C(C4=CC(F)=NC=C4)C(C)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Bastakoty, Dikshya et al. Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell, stem cells and regenerative medicine vol. 2,2 (2016): 10.16966/2472-6990.111. [Content Brief]
[2]. Kang, Sheng. Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities. Human genetics vol. 139,4 (2020): 447-459. [Content Brief]
[3]. Raeisi, Mortaza et al. Porcn as a novel therapeutic target in cancer therapy: A review. Cell biology international vol. 46,12 (2022): 1979-1991. [Content Brief]
[4]. Cheng, Dai et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS medicinal chemistry letters vol. 7,7 676-80. 10 May. 2016, [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GNF-6231 (Standard) Related Classifications
HY-100408R Related Classifications
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