1. Stem Cell/Wnt
  2. Porcupine

GNF-6231 

Cat. No.: HY-100408 Purity: >98.0%
Data Sheet SDS Handling Instructions

GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.

For research use only. We do not sell to patients.
GNF-6231 Chemical Structure

GNF-6231 Chemical Structure

CAS No. : 1243245-18-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $138 In-stock
2 mg $100 In-stock
5 mg $140 In-stock
10 mg $220 In-stock
50 mg $750 In-stock
100 mg $1200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. 1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested 2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration. 3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg. 4) GNF-6231 showed very robust dose-related antitumor efficacy.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2297 mL 11.1485 mL 22.2970 mL
5 mM 0.4459 mL 2.2297 mL 4.4594 mL
10 mM 0.2230 mL 1.1149 mL 2.2297 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

448.49

Formula

C₂₄H₂₅FN₆O₂

CAS No.

1243245-18-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 36 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
GNF-6231
Cat. No.:
HY-100408
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