2. IWP-3

IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α.

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IWP-3 Chemical Structure

IWP-3 Chemical Structure

CAS No. : 687561-60-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 117 In-stock
Solution
10 mM * 1 mL in DMSO USD 117 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 190 In-stock
25 mg USD 400 In-stock
50 mg USD 650 In-stock
100 mg USD 1050 In-stock
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IWP-3 Related Antibodies

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Description

IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α[1][2].

Molecular Weight

484.59

Formula

C22H17FN4O2S3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=C(F)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (51.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0636 mL 10.3180 mL 20.6360 mL
5 mM 0.4127 mL 2.0636 mL 4.1272 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0636 mL 10.3180 mL 20.6360 mL 51.5900 mL
5 mM 0.4127 mL 2.0636 mL 4.1272 mL 10.3180 mL
10 mM 0.2064 mL 1.0318 mL 2.0636 mL 5.1590 mL
15 mM 0.1376 mL 0.6879 mL 1.3757 mL 3.4393 mL
20 mM 0.1032 mL 0.5159 mL 1.0318 mL 2.5795 mL
25 mM 0.0825 mL 0.4127 mL 0.8254 mL 2.0636 mL
30 mM 0.0688 mL 0.3439 mL 0.6879 mL 1.7197 mL
40 mM 0.0516 mL 0.2580 mL 0.5159 mL 1.2898 mL
50 mM 0.0413 mL 0.2064 mL 0.4127 mL 1.0318 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IWP-3687561-60-0IWP3IWP 3Inhibitorinhibitorinhibit

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