2. Stem Cell/Wnt
  3. Wnt
  4. IWP-3

IWP-3 

Cat. No.: HY-100536 Purity: 98.23%
COA Handling Instructions

IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α.

For research use only. We do not sell to patients.

IWP-3 Chemical Structure

IWP-3 Chemical Structure

CAS No. : 687561-60-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 117 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 117 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 190 In-stock
25 mg USD 400 In-stock
50 mg USD 650 In-stock
100 mg USD 1050 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

IWP-3 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α[1][2].

Molecular Weight

484.59

Appearance

Solid

Formula

C22H17FN4O2S3
CAS No.
SMILES

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=C(F)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (51.59 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0636 mL 10.3180 mL 20.6360 mL
5 mM 0.4127 mL 2.0636 mL 4.1272 mL
10 mM 0.2064 mL 1.0318 mL 2.0636 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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IWP-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

IWP-3687561-60-0IWP3IWP 3WntPorcupinePorcnpalmitoylationCK1γ3CK1εCK1αInhibitorinhibitorinhibit

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