1. Cell Cycle/DNA Damage
    Epigenetics
    Autophagy
    Anti-infection
    Apoptosis
  2. HDAC
    Autophagy
    Mitophagy
    Filovirus
    Apoptosis
    HPV
  3. Vorinostat-d5

Vorinostat-d5  (Synonyms: SAHA-d5; Suberoylanilide hydroxamic acid-d5)

Cat. No.: HY-115412 Purity: ≥99.0%
COA Handling Instructions

Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.

For research use only. We do not sell to patients.

Vorinostat-d5 Chemical Structure

Vorinostat-d5 Chemical Structure

CAS No. : 1132749-48-4

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1 mg USD 790 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis[1][4]. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification[7].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

269.35

Formula

C14H15D5N2O3

CAS No.
SMILES

O=C(NO)CCCCCCC(NC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Vorinostat-d5
Cat. No.:
HY-115412
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