1. Anti-infection
  2. Filovirus
  3. 2'-Deoxy-5'-O-DMT-2'-fluorouridine

2'-Deoxy-5'-O-DMT-2'-fluorouridine 

Cat. No.: HY-W008662 Purity: 99.87%
COA Handling Instructions

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.

For research use only. We do not sell to patients.

2'-Deoxy-5'-O-DMT-2'-fluorouridine Chemical Structure

2'-Deoxy-5'-O-DMT-2'-fluorouridine Chemical Structure

CAS No. : 146954-74-7

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  • Purity & Documentation

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Description

2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].

In Vitro

2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concen-trations up to 20 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

548.56

Formula

C30H29FN2O7

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@H]1[C@@H](F)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COC(C3=CC=C(OC)C=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (182.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8230 mL 9.1148 mL 18.2295 mL
5 mM 0.3646 mL 1.8230 mL 3.6459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8230 mL 9.1148 mL 18.2295 mL 45.5739 mL
5 mM 0.3646 mL 1.8230 mL 3.6459 mL 9.1148 mL
10 mM 0.1823 mL 0.9115 mL 1.8230 mL 4.5574 mL
15 mM 0.1215 mL 0.6077 mL 1.2153 mL 3.0383 mL
20 mM 0.0911 mL 0.4557 mL 0.9115 mL 2.2787 mL
25 mM 0.0729 mL 0.3646 mL 0.7292 mL 1.8230 mL
30 mM 0.0608 mL 0.3038 mL 0.6077 mL 1.5191 mL
40 mM 0.0456 mL 0.2279 mL 0.4557 mL 1.1393 mL
50 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.9115 mL
60 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7596 mL
80 mM 0.0228 mL 0.1139 mL 0.2279 mL 0.5697 mL
100 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.4557 mL
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2'-Deoxy-5'-O-DMT-2'-fluorouridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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2'-Deoxy-5'-O-DMT-2'-fluorouridine
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