1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    SARS-CoV
    Filovirus
  3. Galidesivir hydrochloride

Galidesivir hydrochloride (Synonyms: BCX 4430 hydrochloride; Immucillin-A hydrochloride)

Cat. No.: HY-18649 Purity: 99.88%
Handling Instructions

Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM.

For research use only. We do not sell to patients.

Galidesivir hydrochloride Chemical Structure

Galidesivir hydrochloride Chemical Structure

CAS No. : 222631-44-9

Size Price Stock Quantity
10 mM * 1  mL in Water USD 1593 In-stock
Estimated Time of Arrival: December 31
1 mg USD 600 In-stock
Estimated Time of Arrival: December 31
5 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Galidesivir hydrochloride:

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Description

Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM[1][2][3].

IC50 & Target

RdRp inhibitor

In Vitro

Cellular kinases phosphorylate Galidesivir (BCX4430) hydrochloride to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination[1].
Galidesivir hydrochloride effectively inhibits the infection of Vero cells with YFV. The EC50 determined by the neutral red uptake assay is 8.3 μg/ml (24.5 μM)[3].

In Vivo

Galidesivir (BCX4430) hydrochloride is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir hydrochloride has demonstrated pronounced efficacy[1].
Galidesivir hydrochloride (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF)[4].

Animal Model: Female Syrian golden hamsters (hamsters infected with YF virus)[4]
Dosage: 4 mg/kg of body weight
Administration: I.p.; twice daily for 7 days
Result: Significantly improved the survival of hamsters infected with YFV.
Clinical Trial
Molecular Weight

301.73

Formula

C₁₁H₁₆ClN₅O₃

CAS No.

222631-44-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 41 mg/mL (135.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3142 mL 16.5711 mL 33.1422 mL
5 mM 0.6628 mL 3.3142 mL 6.6284 mL
10 mM 0.3314 mL 1.6571 mL 3.3142 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.88%

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Keywords:

GalidesivirBCX 4430Immucillin-ABCX4430BCX-4430DNA/RNA SynthesisSARS-CoVFilovirusSARS coronavirusadenosinenucleosideanalogvirusinfectionpathogenicCOVID-19Inhibitorinhibitorinhibit

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Product Name:
Galidesivir hydrochloride
Cat. No.:
HY-18649
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