1. Apoptosis
  2. Bcl-2 Family

AMG-176 

Cat. No.: HY-101565
Handling Instructions

AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.

For research use only. We do not sell to patients.

AMG-176 Chemical Structure

AMG-176 Chemical Structure

CAS No. : 1883727-34-1

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.

IC50 & Target

Mcl-1

0.13 nM (Ki)

In Vitro

AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6308 mL 8.1538 mL 16.3076 mL
5 mM 0.3262 mL 1.6308 mL 3.2615 mL
10 mM 0.1631 mL 0.8154 mL 1.6308 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

613.21

Formula

C₃₃H₄₁ClN₂O₅S

CAS No.

1883727-34-1

SMILES

ClC1=CC=C2C(CCC[[email protected]@]23CN(C[[email protected]@](CC4)([H])[[email protected]]4([H])[[email protected]](/C=C/C[[email protected]](C)[[email protected]]5C)OC)C6=CC(C(NS5(=O)=O)=O)=CC=C6OC3)=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
AMG-176
Cat. No.:
HY-101565
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AMG-176

Cat. No.: HY-101565