1. Apoptosis
  2. Bcl-2 Family
  3. AMG-176


Cat. No.: HY-101565 Purity: 99.53%
Handling Instructions

AMG-176 est un inhibiteur de MCL-1 qui est puissant, sélectif et oralement actif avec un Ki de 0,13 nM.

AMG-176 is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM.

For research use only. We do not sell to patients.

AMG-176 Chemical Structure

AMG-176 Chemical Structure

CAS No. : 1883727-34-1

Size Price Stock Quantity
1 mg USD 680 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE AMG-176

View All Bcl-2 Family Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


AMG-176 is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM[1][2].

IC50 & Target[1]


0.13 nM (Ki)

In Vitro

AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (Ki=0.13 nM), with potential pro-apoptotic and antineoplastic activities. Upon administration, AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight







ClC1=CC=C2C(CCC[[email protected]@]23CN(C[[email protected]@](CC4)([H])[[email protected]]4([H])[[email protected]](/C=C/C[[email protected]](C)[[email protected]]5C)OC)C6=CC(C(NS5(=O)=O)=O)=CC=C6OC3)=C1


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (101.92 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6308 mL 8.1538 mL 16.3076 mL
5 mM 0.3262 mL 1.6308 mL 3.2615 mL
10 mM 0.1631 mL 0.8154 mL 1.6308 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.39 mM); Clear solution

*All of the co-solvents are provided by MCE.

Purity: 99.53%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


AMG-176AMG176AMG 176Bcl-2 FamilyInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name



Applicant Name *


Email address *

Phone number *


Organization name *

Department *


Requested quantity *

Country or Region *



Bulk Inquiry

Inquiry Information

Product Name:
Cat. No.:
MCE Japan Authorized Agent: