1883727-34-1
1883727-34-1
Chemical Structure
Tapotoclax
Synonym(s): AMG-176
- CAS No.: 1883727-34-1
- Formula:C33H41ClN2O5S
- Molecular Weight:613.21
InChIKey: JQNINBDKGLWYMU-GEAQBIRJSA-N
SMILES: ClC1=CC=C2C(CCC[C@@]23CN(C[C@@](CC4)([H])[C@]4([H])[C@H](/C=C/C[C@H](C)[C@H]5C)OC)C6=CC(C(NS5(=O)=O)=O)=CC=C6OC3)=C1
Biological Activity: Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tapotoclax | 98.35% | Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM. | ||||||||||||||||||||
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References
- [1]. Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. [Content Brief]
- [2]. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142. [Content Brief]
Keywords
