Mcl-1 Inhibitor

Mcl-1 Inhibitors (41):

Cat. No.	Product Name	Effect	Purity

HY-100741

S63845	Inhibitor	99.94%
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a K_d of 0.19 nM for human MCL1.

HY-50907

ABT-737	Inhibitor	99.96%
ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively.

HY-19741

A-1331852	Inhibitor	99.65%
A-1331852 is an orally available BCL-XL selective inhibitor with a K_i of less than 10 pM.

HY-101533

AZD-5991	Inhibitor	99.50%
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC₅₀ of 0.7 nM in FRET assay and a K_d of 0.17 nM in surface plasmon resonance (SPR) assay.

HY-114855

BT2	Inhibitor	99.56%
BT2 is a BCKDC kinase (BDK) inhibitor with an IC₅₀ of 3.19 μM.

HY-145825A

(E)-Mcl-1 inhibitor 7	Inhibitor
(E)-Mcl-1 inhibitor 7 (Example 34) is a Mcl-1 inhibitor (K_i: <1 nM, IC₅₀: <500 nM).

HY-138071

8α-Tigloyloxyhirsutinolide 13-O-acetate	Inhibitor
8α-Tigloyloxyhirsutinolide 13-O-acetate is a potent and orally active STAT3 inhibitor.

HY-112218

MIK665	Inhibitor	99.72%
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor.

HY-10969

Obatoclax Mesylate	Inhibitor	99.74%
Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a K_i of 220 nM for BCL-2.

HY-101565

Tapotoclax	Inhibitor	99.80%
Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a K_i of 0.13 nM.

HY-12468

A-1210477	Inhibitor	99.40%
A-1210477 is a potent and selective inhibitor of MCL-1 with a K_i of 0.45 nM.

HY-N0087

Gambogic Acid	Inhibitor	98.85%
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi.

HY-15464A

(R)-(-)-Gossypol acetic acid	Inhibitor	98.02%
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol.

HY-125877

PROTAC Mcl1 degrader-1	Inhibitor	98.13%
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC₅₀ of 0.78 μM.

HY-15191

Sabutoclax	Inhibitor
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC₅₀s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

HY-12020

TW-37	Inhibitor	99.27%
TW-37 is a potent Bcl-2 inhibitor with K_i values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.

HY-112859

VU0661013	Inhibitor	98.52%
VU661013 is a potent and selective MCL-1 inhibitor.

HY-15613

Maritoclax	Inhibitor	99.97%
Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC₅₀ value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC₅₀ > 80 μM).

HY-125876

PROTAC Bcl2 degrader-1	Inhibitor	98.78%
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC₅₀, 4.94 μM; DC₅₀, 3.0 μM) and Mcl-1 (IC₅₀, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.

HY-129478

TC11	Inhibitor	98.04%
TC11 is a MCL1 degrader.

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