100823-03-8
Chemical Structure
TC11
- CAS No.: 100823-03-8
- Formula:C20H22N2O2
- Molecular Weight:322.40
IUPAC Name: 5-amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione
InChIKey: NRPIRIUWEKTNGQ-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O
Biological Activity: TC11 is a MCL1 degrader and apoptosis inducer. TC11 induces sustained CDK1 activation to phosphorylate and degrade MCL1, activates caspase-3, -8, and -9, inhibits centrosomal-regulatory NPM function to block centrosomal clustering, and triggers apoptosis independent of the cereblon pathway. TC11 blocks tumor cell proliferation in vitro and acts against tumor xenografts in vivo. TC11 can be used for the research of multiple myeloma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TC11 | 99.55% | TC11 is a MCL1 degrader and apoptosis inducer. TC11 induces sustained CDK1 activation to phosphorylate and degrade MCL1, activates caspase-3, -8, and -9, inhibits centrosomal-regulatory NPM function to block centrosomal clustering, and triggers apoptosis independent of the cereblon pathway. TC11 blocks tumor cell proliferation in vitro and acts against tumor xenografts in vivo. TC11 can be used for the research of multiple myeloma. | ||||||||||||||||||||
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References
- [1]. Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochemical and biophysical research communications. 2020 Jan 01;521(1):252-258. [Content Brief]
- [2]. Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PloS one. 2012;7(6):e38878. [Content Brief]
