100823-03-8
100823-03-8
Chemical Structure
TC11
- CAS No.: 100823-03-8
- Formula:C20H22N2O2
- Molecular Weight:322.40
IUPAC Name: 5-amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione
InChIKey: NRPIRIUWEKTNGQ-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O
Biological Activity: TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death [1][2] during prolonged mitotic arrest.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TC11 | 99.55% | TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death during prolonged mitotic arrest. | ||||||||||||||||||||
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References
- [1]. Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258. [Content Brief]
- [2]. Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878. [Content Brief]
Keywords
