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  3. Indobufen

Indobufen (Synonyms: Ibustrin)

Cat. No.: HY-18763
Handling Instructions

Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes.

For research use only. We do not sell to patients.

Indobufen Chemical Structure

Indobufen Chemical Structure

CAS No. : 63610-08-2

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Description

Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes[1].

IC50 & Target[1]

COX

 

In Vitro

Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels. Indobufen inhibits TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen reduces the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

295.33

Formula

C₁₈H₁₇NO₃

CAS No.

63610-08-2

SMILES

O=C(O)C(CC)C1=CC=C(N(CC2=C3C=CC=C2)C3=O)C=C1

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Room temperature in continental US; may vary elsewhere

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Product Name:
Indobufen
Cat. No.:
HY-18763
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Indobufen

Cat. No.: HY-18763