2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Carbonic anhydrase inhibitor 16

Carbonic anhydrase inhibitor 16 

Cat. No.: HY-163109 Purity: 98.00%
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Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (Ki: 28.5 nM, 2.2 nM).

For research use only. We do not sell to patients.

Carbonic anhydrase inhibitor 16 Chemical Structure

Carbonic anhydrase inhibitor 16 Chemical Structure

CAS No. : 4479-70-3

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Description

Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (Ki: 28.5 nM, 2.2 nM)[1].

IC50 & Target

Ki: 28.5 nM (hCA I), 2.2 nM (hCA II)[1]
Molecular Weight

302.31

Formula

C14H10N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=C(S(N)(=O)=O)C=C2)C(C3=C1C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (330.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3079 mL 16.5393 mL 33.0786 mL
5 mM 0.6616 mL 3.3079 mL 6.6157 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3079 mL 16.5393 mL 33.0786 mL 82.6966 mL
5 mM 0.6616 mL 3.3079 mL 6.6157 mL 16.5393 mL
10 mM 0.3308 mL 1.6539 mL 3.3079 mL 8.2697 mL
15 mM 0.2205 mL 1.1026 mL 2.2052 mL 5.5131 mL
20 mM 0.1654 mL 0.8270 mL 1.6539 mL 4.1348 mL
25 mM 0.1323 mL 0.6616 mL 1.3231 mL 3.3079 mL
30 mM 0.1103 mL 0.5513 mL 1.1026 mL 2.7566 mL
40 mM 0.0827 mL 0.4135 mL 0.8270 mL 2.0674 mL
50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6539 mL
60 mM 0.0551 mL 0.2757 mL 0.5513 mL 1.3783 mL
80 mM 0.0413 mL 0.2067 mL 0.4135 mL 1.0337 mL
100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8270 mL
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Carbonic anhydrase inhibitor 16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbonic anhydrase inhibitor 164479-70-3Carbonic anhydrase inhibitor16Carbonic anhydrase inhibitor-16Carbonic AnhydraseCarbonate dehydrataseCarbonic anhydrasemolecular dockingmolecular dynamicsphthalyl sulphamoyl derivativesInhibitorinhibitorinhibit

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