1. Apoptosis
    Cell Cycle/DNA Damage
  2. Caspase
    Bcl-2 Family
    CDK
  3. TC11

TC11 

Cat. No.: HY-129478 Purity: 98.04%
Handling Instructions

TC11 is a MCL1 degradator and Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory drugs as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest.

For research use only. We do not sell to patients.

TC11 Chemical Structure

TC11 Chemical Structure

CAS No. : 100823-03-8

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5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TC11 is a MCL1 degradator and Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory drugs as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2].

IC50 & Target

CDK1

 

Caspase-9

 

MCL1

 

In Vitro

Cell Viability Assay[1]

Cell Line: KMS34 cells
Concentration: 0~30 μM
Incubation Time: 24 hours
Result: Induced cell death.

Western Blot Analysis[1]

Cell Line: KMS34 cells
Concentration: 5 μM
Incubation Time: 0~48 hours
Result: Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression.

Cell Cycle Analysis[1]

Cell Line: KMS34 cells
Concentration: 5 μM
Incubation Time: 24 hours
Result: Induced M arrest.
In Vivo

TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34[1].
TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression[1].
TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

322.40

Formula

C₂₀H₂₂N₂O₂

CAS No.
SMILES

O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

TC11TC 11TC-11CaspaseBcl-2 FamilyCDKCyclin dependent kinaseAntitumorImmunomodulatoryPhenylphthalimideDerivativeApoptoticDeathMitoticInhibitorinhibitorinhibit

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TC11
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