2. Apoptosis Cell Cycle/DNA Damage
  3. Caspase Bcl-2 Family CDK
  4. TC11

TC11 is a MCL1 degrader. TC11 is also a Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory agents as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest.

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TC11 Chemical Structure

TC11 Chemical Structure

CAS No. : 100823-03-8

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Based on 1 publication(s) in Google Scholar

TC11 Related Antibodies

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Description

TC11 is a MCL1 degrader. TC11 is also a Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory agents as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2].

IC50 & Target

CDK1

 

Caspase-9

 

MCL1

 

In Vitro

TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34[1].
TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression[1].
TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TC11 Related Antibodies

Cell Viability Assay[1]

Cell Line: KMS34 cells
Concentration: 0~30 μM
Incubation Time: 24 hours
Result: Induced cell death.

Western Blot Analysis[1]

Cell Line: KMS34 cells
Concentration: 5 μM
Incubation Time: 0~48 hours
Result: Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression.

Cell Cycle Analysis[1]

Cell Line: KMS34 cells
Concentration: 5 μM
Incubation Time: 24 hours
Result: Induced M arrest.
Molecular Weight

322.40

Formula

C20H22N2O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (155.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1017 mL 15.5087 mL 31.0174 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.75 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1017 mL 15.5087 mL 31.0174 mL 77.5434 mL
5 mM 0.6203 mL 3.1017 mL 6.2035 mL 15.5087 mL
10 mM 0.3102 mL 1.5509 mL 3.1017 mL 7.7543 mL
15 mM 0.2068 mL 1.0339 mL 2.0678 mL 5.1696 mL
20 mM 0.1551 mL 0.7754 mL 1.5509 mL 3.8772 mL
25 mM 0.1241 mL 0.6203 mL 1.2407 mL 3.1017 mL
30 mM 0.1034 mL 0.5170 mL 1.0339 mL 2.5848 mL
40 mM 0.0775 mL 0.3877 mL 0.7754 mL 1.9386 mL
50 mM 0.0620 mL 0.3102 mL 0.6203 mL 1.5509 mL
60 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2924 mL
80 mM 0.0388 mL 0.1939 mL 0.3877 mL 0.9693 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7754 mL
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TC11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC11100823-03-8TC 11TC-11CaspaseBcl-2 FamilyCDKCyclin dependent kinaseAntitumorImmunomodulatoryPhenylphthalimideDerivativeApoptoticDeathMitoticInhibitorinhibitorinhibit

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