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Art. -Nr.: HY-114545

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5HPP-33

Name: 5HPP-33
Brand: MedChemExpress
SKU: HY-114545
Price: 132.00 USD
Availability: InStock
Rating: 5 (1 reviews)

5HPP-33 is an inhibitor for tubulin polymerization with IC₅₀ of 8.1 μM. 5HPP-33 inhibits the proliferation of leukemia cell and multiple myeloma cells with IC₅₀ of 1-10 μM, arrests the cell cycle at G2/M phase, and induces apoptosis.

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CAS. Nr.: 105624-86-0
Formel: C₂₀H₂₁NO₃
Molecular Weight:323.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

5HPP-33 Chemical Structure

CAS. Nr.: 105624-86-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	5.74 μM Compound: 5HPP-33	Antiproliferative activity against human DU145 cells assessed as growth inhibition by MTS assay Antiproliferative activity against human DU145 cells assessed as growth inhibition by MTS assay	[PMID: 24169233]
HeLa	IC₅₀	0.53 μM Compound: 5HPP-33	Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation	[PMID: 17845850]
MDA-MB-231	IC₅₀	5.35 μM Compound: 5HPP-33	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition by MTS assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition by MTS assay	[PMID: 24169233]
MOLT-4	IC₅₀	15 μg/mL Compound: 15	Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
MOLT-4	IC₅₀	21.3 μg/mL Compound: 15	Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
MOLT-4	IC₅₀	46.4 μM Compound: 15	Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
MOLT-4	IC₅₀	65.9 μM Compound: 15	Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
PC-3	IC₅₀	8.3 μM Compound: 5HPP-33	Antiproliferative activity against human PC3 cells assessed as growth inhibition by MTS assay Antiproliferative activity against human PC3 cells assessed as growth inhibition by MTS assay	[PMID: 24169233]
WI-38	IC₅₀	12.7 μg/mL Compound: 28	The cytotoxicity of the compounds assessed using human embryonic lung fibroblast WI-38 cells at (39 micro M) The cytotoxicity of the compounds assessed using human embryonic lung fibroblast WI-38 cells at (39 micro M)	[PMID: 9288167]

Chemical Information

CAS. Nr. 105624-86-0
Molecular Weight 323.39
Formel C₂₀H₂₁NO₃
SMILES

O=C1C2=CC=C(C=C2C(N1C3=C(C(C)C)C=CC=C3C(C)C)=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Inatsuki S, et al. Tubulin-polymerization inhibitors derived from thalidomide. Bioorg Med Chem Lett. 2005 Jan 17;15(2):321-5. [Content Brief]

[2]. Iguchi T, et al. 5HPP-33, a Novel Tubulin-Polymerization Inhibitor Derived from Thalidomide, Directly Inhibits Proliferation and Induces Apoptosis of Human Multiple Myeloma Cells[J]. Blood, 2005, 106(11): 1586.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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